Executive Meddling: The movie was intended to be an erotic horror flick about a cartoonist who had sex with a sexy cartoon woman he created named Debbie Dallas and is now the father of a half-human, half-cartoon girl who considers herself a freak and goes on a rampage against the man who spawned her. Sadly, Frank Mancuso Jr. and Kim Basinger nixed that at the last minute to make it more kid-friendly (though it really doesn't come off that way) and into the complete and total bomb we know it as.
Hey, It's That Guy!: Milton Knight worked on this film, as background character designer. He would later be known for working on Adventures of Sonic the Hedgehog. His website has character designs for the film, while others that didn't get into the finished product.
What Could Have Been: The original horror concept (in which Jack has sex with Holli [who was actually named Debbie Dallas, after the infamous 1970s porno, Debbie Does Dallas] and Holli has a half-cartoon, half-human daughter who sees herself as a freak and plots to kill her parents) would have made a much better movie than a Roger Rabbit ripoff we have now. Blame Frank Mancuso Jr. and Kim Basingerfor screwing it up.
Originally, Candi Milo wasn't supposed to be the voice of Lonette. She was only there as a line-feeder for the other actors, but she was put in after the producers saw that she was great with doing voices and acting.
Brad Pitt and Drew Barrymore were Ralph Bakshi's original choices for the roles of Deebs and Holli.