- Acting for Two: Technically it's one on-screen role and one voice role, but Kevin Allen plays the French waiter and also provides the voice of "Cannonball" Taffy O'Jones in "Finger".
- Actor-Shared Background: There was a recurring gag in the show, which Eddie was asked if he was related to Adolf Hitler and Eddie would reply "Yes!" and had thought that his mother's name was Adolf, although Eddie had been abandoned as a baby. In real-life, Adrian Edmondson's father was named Adolf.
- Completely Different Title: In Spain the show was known as La pareja basura (The Trash Couple).
- The Danza: Richard Mayall and Adrian Edmondson.
- Dyeing for Your Art: Ade Edmondson shaved his head to play Eddie.
- Irony as She Is Cast: In the series, Eddie can't cook to save his life (he once resorted to eating lard when he was hungry) and has to rely on Richie's terrible cooking. In real life, Adrian Edmondson is actually a very talented chef who won the 2013 edition of Celebrity MasterChef.
- I Want You to Meet an Old Friend of Mine: Christopher Ryan — who played the suave Mike alongside Adrian Edmondson and Rik Mayall in The Young Ones — occasionally shows up as Dave Hedgehog. Sadly, Nigel Planer turned down the role of Spudgun, thus denying us a whole cast reunion. (Not to mention reuniting the cast of Filthy Rich & Catflap).
- Out of Order: The third episode, "Contest", was supposed to be the pilot. The noticeable differences are in the set with the organ being on the "fourth" wall, stairs opposite way, and the fact Richie has shorter hair than usual as well as Eddie visibly showing hair and missing his sideburns indicate that this episode was filmed much earlier than the other episodes in the series.
- Throw It In!: Rik Mayall accidentally hit Adrian with a Groin Attack on The Big Number 2 stage show. Adrian's next line is "It's alright Richie, I have 3 fucking kids already."
- Too Soon: The camping episode ("'s Out") was omitted from the original 1992 run completely due to a then recent murder on Wimbledon Common; it was eventually aired in 1995.
- What Could Have Been:
- There were plans for a fourth season, which would have continued by revealing that Richie and Eddie getting gunned down by the SAS at the end of "Carnival" was a dream (mocking ''Dallas). Another option was to have Richie and Eddie simply survive their shot-wounds, and let the show continue as if nothing has happened.
- Over the years, Rik Mayall and Adrian Edmondson repeatedly considered to return as their Bottom characters. According to Edmondson, one of those ideas involved an elderly Richie and Eddie living in a retirement home, "[where] we will be hitting each other with colostomy bags". This idea never came to fruition when Mayall died in 2014.
- Working Title: Adrian Edmondson and Rik Mayall originally planned to call the series Your Bottom - so that viewers would be heard to say such things as, "I saw Your Bottom on television last night".
- You Look Familiar: Helen Lederer pulls double-duty as a nurse in "Apocalypse" and as Richie's would-be bride Natasha in "Digger".
Lyrics to Richie's version of The Sailor's Hornpipe:
Do your balls hang low?
Can you swing 'em to and fro?
Can you tie 'em in a knot?
Can you tie 'em in a bow?
Do you get a funny feeling when they're hanging from the ceiling?
Oh you'll never be a sailor if your balls hang low!