* Remember Pinoko, the ClingyJealousGirl sidekick of Dr. Manga/BlackJack in the anime and manga of the same name? Well, would you believe that she's an ArtificialHuman constructed by the aforementioned doctor from a woman's underdeveloped parasitic twin and some spare parts while he was drunk? It's totally the truth, we swear.
** There's also an episode that deals with a love triangle between a young doctor, his fiance and - get this - a ''surgically altered, sapient deer''. [[http://static.tvtropes.org/pmwiki/pub/images/forrealspeople.JPG We have pictures if you don't believe us.]]
** There's a chapter in the manga in which Black Jack operates on his own intestines... in the middle of the Australian Outback... after being stranded for several days... while being attacked by dingoes... [[BadAss Yeah.]]
* HilariousInHindsight: Black Jack shares his [[Creator/KirkThornton English]] and [[Creator/AkioOhtsuka Japanese]] voice actors with a ''Franchise/KingdomHearts'' villain; in Japanese, he's Ansem, Seeker of Darkness [[spoiler: (as well as Terra-Xehanort)]], and in English, he's Saïx. Coincidently, [[spoiler: they are both members of the True Organization XIII, as revealed in ''VideoGame/KingdomHearts3DDreamDropDistance'']].
* {{Jossed}}: The second Kei story seems to have been written specifically to disabuse fans of the notion that [[spoiler: Kei/Megumi had been physically transformed into a man by the removal of her ovaries and uterus.]]
* LifeImitatesArt[=/=]RealitySubtext: The manga story ''Tenacity'' is pretty heart-wrenching in light of the author's final fate. What makes it even worse it that the dying doctor's personal physician is "played" by Tezuka himself.
** The same can be said of the Black Jack movie, the plot of which revolves around "super-humans" succumbing to disease and fatality while trying to do what they love.