* CelebrityVoiceActor: In ''The Two Doctors of Darkness'', Kiriko, Rock and Goa are respectively voiced by Takeshi Kaga, Yuma Ishigaki and Shinya Owada.
* DuelingDubs: In Latin America, there's two dubbed versions of the 2004 TV series, one dubbed in Colombia (and used by Animax) and another most recent one, dubbed in Mexico. The Mexican one was done with the explicit purpose of replacing the Colombian one, as the quality of the latter is... ''not very good'', to put it in kinder words.
* {{Jossed}}: The second Kei story seems to have been written specifically to disabuse fans of the notion that [[spoiler: Kei/Megumi had been physically transformed into a man by the removal of her ovaries and uterus.]]
* LifeImitatesArt[=/=]RealitySubtext: The manga story ''Tenacity'' is pretty heart-wrenching in light of the author's final fate. What makes it even worse it that the dying doctor's personal physician is "played" by Tezuka himself.
** The same can be said of the Black Jack movie, the plot of which revolves around "super-humans" succumbing to disease and fatality while trying to do what they love.