Remember Pinoko, the Clingy Jealous Girl sidekick of Dr. Black Jack in the anime and manga of the same name? Well, would you believe that she's an Artificial Human constructed by the aforementioned doctor from a woman's underdeveloped parasitic twin and some spare parts while he was drunk? It's totally the truth, we swear.
There's a chapter in the manga in which Black Jack operates on his own intestines... in the middle of the Australian Outback... after being stranded for several days... while being attacked by dingoes... Yeah.
Black Jack even shares his English and Japanese voice actors with a Kingdom Hearts villain; in Japanese, he's Ansem, Seeker of Darkness (as well as Terra-Xehanort), and in English, he's Saïx. Coincidently, they are both members of the True Organization XIII, as revealed in Kingdom Hearts 3D: Dream Drop Distance.
Jossed: The second Kei story seems to have been written specifically to disabuse fans of the notion that Kei/Megumi had been physically transformed into a man by the removal of her ovaries and uterus.
Life Imitates Art/Reality Subtext: The manga story Tenacity is pretty heart-wrenching in light of the author's final fate. What makes it even worse it that the dying doctor's personal physician is "played" by Tezuka himself.