- Actor Allusion: At one point, while the girls are trying to come up with ideas to bring attention to the league, Mae suggests letting her bosoms pop out. Doris shoots the idea down: "You think there are men in this country who ain't seen your bosoms?" At the time the film was made, Madonna had caused a controversy by showing herself in public.
- Madonna in general, who's essentially playing a 1940s version of herself.
- AFI's 100 Years... 100 Movie Quotes:
- "There's no crying in baseball": #54.
- Billing Displacement: Tom Hanks, Geena Davis, and Madonna are listed as the three main actors in promotional material, and home video, despite the fact that the characters Dottie and Kit are clearly the main stars, and Lori Petty has a much larger role than Madonna (Although Madonna also contributed the movie's theme, "This Used to Be My Playground").
- The Cast Showoff: Madonna gets to show off her The '40s dancing skills.
- Completely Different Title: In Japan, the film was released as プリティ・リーグ (Pretty Leagues).
- Dyeing for Your Art: Lori Petty is a brunette and had to dye her hair red to look more believable as Geena Davis' sister.
- All actresses took actual baseball training for six days a week, for several months. Even Geena Davis, among the last to be cast, mastered baseball skills within a few weeks.
- Executive Meddling: The producers wanted Jimmy and Dottie to hook up in the end. They also pushed for Dottie to save Jimmy from his drinking. The director responded with a single scene on the bus where Jimmy ends the conversation saying it was "time for a drink." Dottie takes his flask and hands him a soda.
- Font Anachronism: The movie is set in 1943. The "Catch A Foul-Get A Kiss" banner is printed in the font "Banco", which was created in 1951.
- Playing Against Type: Tom Hanks to some extent. Jimmy Dugan eventually proves to have a heart of gold, but he's arguably the sleaziest character Hanks has ever played.
(Jimmy has just signed a baseball for a little boy)
Little Boy: [reading] "Avoid the clap, Jimmy Dugan." Cool!
Jimmy Dugan: Hey, that's good advice!
- Real-Life Relative: Penny's brother Garry Marshall as Walter Harvey, and daughter Tracy Reiner as Betty "Spaghetti" Horn.
- Recycled: The Series: Had a six episode run in 1993 as a half hour Sitcom. Garry Marshall, Jon Lovitz, Megan Cavanagh (Marla Hooch) and Tracy Reiner (Betty Horn) reprised their roles from the movie. Penny Marshall directed the pilot, while Tom Hanks directed an episode.
- Throw It In: During his scene on the farm, John Lovitz kept getting interrupted by the cows' mooing, prompting him to ad-lib, "Will you shut up?!"
- What Could Have Been: In the original cut, there was a subplot where Marla Hooch got married right after the Western Union scene. She tells the girls she's pregnant, but asks them not to tell the coaches who would kick her off her team, and the girls make a promise not to slide into second when she's playing. Then in a game, Dottie's so distracted she doesn't realize Marla's playing second, and slides hard enough into her stomach to cause her to go to the hospital. The scene where Dottie is weeping was originally supposed to be her guilt over what happened with Marla, rather than a direct segue from Betty's tragedy.
- And she's distracted because of another dropped subplot—growing romantic tension with Jimmy. They've shared a kiss—this and the fight with Kit are what spurs her decision to quit the team—and have been arguing about it, which is why Dottie is oblivious to the warnings about Marla. Her tears are guilt over injuring Marla and her slight infidelity.
- Lindsay Frost originally signed on to play Mae, but dropped out when her TV pilot was picked up.
- Debra Winger, Brooke Shields, Laura Dern, Sean Young, Demi Moore, Jennifer Jason Leigh, Ally Sheedy, and Kelly Mc Gillis, were considered for the role of Dottie.
- James Belushi was considered for the role of Jimmy Dugan.
- Moira Kelly and Molly Ringwald were considered for the role of Kit, (Kelly had to drop out when she injured her ankle filming The Cutting Edge.)
- Marisa Tomei, Farrah Fawcett, KD Lang, were considered for roles as well.
- Written-In Infirmity: A consequence of Method Acting: None of the actresses wanted a stunt double, so they did many of the stunts themselves. Their injuries were written into the film. So when you see Rosie O'Donnell wearing a knee-brace, or Renee Coleman sporting a bloody bruise the size of a frying pan on her leg, that's because they really hurt themselves. (The bruises the size of frying pans, along with open, seeping wounds, were Truth in Television; one player would recount years later how she had to sit in the dugout between innings on what was essentially a hemorrhoid donut for an entire game because the team's chaperone didn't want her to get blood all over her uniform.)
- The bruise Coleman had from the slide was real. It didn't go away for over a year.
- In the scene where Dottie catches a fast-pitch from Doris bare-handed, one of the real players from the league (and a consultant) claims this was a tennis ball with a baseball skin covering it, to help avoid hurting the actresses unnecessarily.