The Slender Man ends up killing, enslaving, or inducing madness in almost every person he encounters. It's in his nature. Slender bloggers are Doomed by Canon. The best you can hope for is delaying him long enough to run and spending the rest of your days looking over your shoulder, waiting for him to catch up. The tradition was probably started by Just Another Fool, in which the Slender Man killed every single character involved in the blog.
It is debatable on how infallible this is. Marble Hornets continues to be updated even after the protagonists are caught be Slendy, and somehow escape. Everyman Hybrid looks like it's headed this way, considering how much of the cast has been killed off.
It all balances out in the end, though. Riz's family moves away and disowns him, and though he manages to make a decent living off of his fame, one of the escapees eventually tracks him down and kills him in his own home.
In SOTF-TV, Karen Ruiz goes home safe and sound after killing 10 people.
Due to the dozens of SCPs that spell absolutely certain doom for the Foundation, civilization, the human race, Earth, the galaxy, or reality itself, this is eventually going to happen... despite the Foundation's best efforts to avert it.
The Nostalgia Critic's 2008 Halloween Special had Teddy Ruxpin come back from being beheaded, put a gun in the Critic's mouth, force him to do a positive review, and kill him when he screams for help.
In Yu-Gi-Oh! The Abridged Series Episode 49, Crumbs surprisingly defeats Tea and takes control of her body, despite it being a sharp deviation from the original source material, which the series rarely defies.
The Undersiders in Worm manage, through a combination of coincidence and competence, to take over the city over the course of the first nineteen character arcs.
Heavily mitigated by the fact that the Undersiders are the protagonists, at most barely as evil as the government, more interested in the safety of the citizenry than the local government leaders, by far superior to all of the villains they dispose of, and at the hands of the Undersiders, Brockton Bay's quality of life drastically improves after several catastrophic events. And the protagonist joins the government, greatly improving it's efficiency as a crime-fighting organisation, and the Undersiders go on to being instrumental in saving the world.
Though he is consigned to a Fate Worse than Death, Jack Slash still manages to convince Scion to destroy humanity.
Tom Collins, the leader of SWAG, got his wish for Demo Reel productions to be destroyed and Donnie to die miserable and alone.