- Shrek explaining to Donkey why he is the way he is:
Shrek: It's the world that has a problem with me! People take one look at me and say, "Ahh! Help! Run! A big, stupid, ugly ogre..." [depressed]' They judge me before they even know me.
- And don't forget the scene after Shrek and Fiona split up, and everything's going as planned for Fiona and Lord Farquaad's wedding, but both are completely miserable. What really pushes it into tearjerker territory is the heartbreaking Hallelujah by Rufus Wainright playing in the background.
- The misunderstanding where Shrek overhears Fiona saying, "Who could ever love a beast so hideous and ugly?" is painfully hard to watch. Extra points for being depressing both from Fiona's side and Shrek's side of the conversation.
- "I live alone! Me! My swamp! Nobody else, understand? Especially useless, annoying, pathetic talking donkeys!" Just...that. During the whole line, he's obviously trying not to cry, and for once in his life he's let himself have a friend, let himself fall in love, and he thinks it can't be and is trying to shove Donkey out of his life. To make it worse, there's Donkey's clearly-hurt expression and
Donkey: But...I thought—
Shrek: Yeah, well you know what? You thought wrong!
- Lord Farquaad's attempt at a breaking speech towards Shrek begins with "It's rude enough being alive when no one wants you!" Evil or not, that was just uncalled for.
- The Twist Ending-
Fiona: [In her ogre form] I'm supposed to be beautiful...
Shrek: But you are beautiful.
- In the Broadway musical, there is the closing number of the first act "Who I'd Be" where Shrek is talking to Donkey about the things he would do if he weren't an ogre. The real clincher is Shrek's line, which delivers just how alone and isolated he feels:
Shrek: An ogre always hides / An ogre's fate is known / An ogre always stays in the dark and all alone.