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Tearjerker: SF Debris
Chuck has repeatedly mentioned that he has children; twin boys, to be precise. However, in the "Real Life" review, he takes a break from the Doctor losing his daughter in a holographic simulation of family life...to talk about how his sons were born ten weeks early and at two pounds each. He talks about how the second worse pain is when they stop breathing and you hope for them that they'll continue. Fortunately, they were able to beat the 49% survival probability.
After his review of Dear Doctor SF shows a clip on Benjamin Sisko from In The Pale Moonlight where he says that saving a huge number of people is worth a guilty conscience...and then a clip of Phlox from Dear Doctor saying how Captain Archer now has his respect for letting an entire species die.
Janeway refusing to listen to Seven's request to save her father, who she's just reunited with.
Several of his tributes:
The tribute montage to TNG set to "Under Pressure" in the "All Good Things" review.
The tribute for Data in Nemesis was much better then the movie allegedly gave to him.