- By far the biggest was J.T.'s Death.
- A close second is "My Body is a Cage," seeing all that Adam went through and how difficult it is for a transgender person.
- Another contender is "Time Stands Still" and the aftermath of the shooting. Seeing different people's reactions to the shooting is heartbreaking, and it's set to Melissa McClelland's Rooftop. By the time it gets to the final shot of Emma and Toby, it's pretty difficult to remain dry-eyed.
- After Alli loses her virginity, and they show her sitting alone in her ridiculously girly kiddy bedroom, being kissed goodnight by her mom, and making it all too clear that she was not ready for this.
- Jane Says.
- Emma's real father.
- When Sean's about to be shipped off to Afghanistan, he breaks down in front of Snake and admits that he's scared of what could happen to him while in combat.
- Liberty giving up her baby.
- Clare being sexually harassed by Asher.
- Rick being bullied.
- KC leaving at the end of "Rusty Cage".
- Campbell's suicide in the episode "Bittersweet Symphony." Credit must be given to all the cast members for portraying such a wide range of realistic reactions to the suicide, with particular praise for Demetrius Joyette showing Dallas' guilt.
- Sean breaking down in front of his parents because he killed Rick.
- Craig's abuse storyline in "When Doves Cry," and then its conclusion in "Tears Are Not Enough".
- Maya finally breaking down after Campbell's suicide towards the end of "Zombie".
Maya: He broke up with me by killing himself! I HATE HIM! I HATE HIM! I feel like I'm never gonna be happy again! And everyday, it just gets worse and worse— I can't miss him anymore! I can't, I don't want to! [beat] He never even said goodbye...
- Darcy realizing she was raped and the fallout from it, especially in "Live to Tell"
- KC and Jenna deciding to give up their son for adoption in "Extraordinary Machine".
- Imogen finding her dog... after he's been accidentally run over by her dad's car.
- Drew's reaction to finding out about Adam's death. He says Adam's name and collapses into his mom's arms sobbing.
- Dallas's reaction is just as bad. He gives a kind of traumatized stare and just backs away. Especially sad when you realize that this is the second time a friend of his has died, meaning he is probably remembering Cam's death all over again.
- Becky, Drew, and Clare all have extremely heartbreaking moments in the next episode. Drew is completely torn up about his death, blaming himself for Adam's death and falling apart completely in front of Bianca at one point. Clare's cancer goes into remission, but she feels guilty about going to Adam's memorial because she got to live and he didn't. Becky tries to throw a bonfire in honor of Adam, but believes that all of his friends absolutely hate her and tries so hard to make it perfect. Of course, a large amount of people show up, leading to the most devastating speech that she gives while in tears.
Becky:So many people came. Just not the one I wanted... I'm so lost without you. Bye Adam Torres... I love you.
- "Unbelievable" is basically a two-part, nonstop tearjerker. Nearly every moment Zoe's onscreen during this episode is devastating. Then we have the scenes when Becky finds out that her brother Luke was one of the players who raped Zoe, and then decides the right thing to do is turn him into the authorities at the end despite knowing that it will likely destroy her family.
- This exchange from part 2 of "Bittersweet Symphony" between Jake and Eli, as they discuss Eli discovering Cam's body in the greenhouse:
Jake: Is my garden gonna be haunted now?
Eli: Nah... Just me...
- Doubles as Nightmare Fuel, ESPECIALLY in the episodes that follow...
- Darcy's reaction to finding out she was raped. She breaks down in front of Manny, and cuts her wrists in the school showers in an attempted suicide. Manny finds her, but it takes her a very long time to truly recover.
- The beginning of Hunter's stay in the psychiatric care facility. Obviously he needs help, but he reacts to it like his family is locking him in prison and tries to escape multiple times, and it takes a few episodes for him to trust them again—not to mention be able to trust his own thoughts.
- That freaking ending to #OMFG from Degrassi: Next Class. After the girls win the volleyball match and everything seems to be going well, it turns out half the cast ended up in a bus crash. The image they show of the crashed bus alone can send a viewer into tears, but what really hits the nail is when Shay tries calling Tiny, holding back tears and his voicemail picks up. The mere fact half of the characters we got to know and love or hate are probably dead, most with an arc in the show. Plus knowing this show next season could very well have all the characters on the bus die, half or a couple. Either way this was an incredible cliffhanger.
- The impact of the bus crash is also a major Tear Jerker. Multiple characters are affected: Miles is worried about Tristan, Zoe about Grace, Shay and Lola about Tiny, Frankie about Jonah, and so many major characters are in danger.
- Zoë's closeted self loathing and Self-Harm storyline in the same season. Especially this line, after Grace urges her to come out and not resort to self harm.
Zoë: Why? So some stupid girl can break my heart again?
- Maya's depression and isolation from her friends in season three, cumulating in Maya attempting suicide.
- Esme's backstory is surprisingly tragic; when she was ten she found her mom overdosed and couldn't save her, which resulted in her father blaming Esme for her mother's death.
- Everyone's reactions to Maya's suicide attempt. Grace and Jonah especially, as they brushed her off when she needed help and blame themselves for it. Ultimately it's Esme, of all people, who tries to keep them calm, saying that they can never know what someone is really thinking or what they might do.
Tearjerker / Degrassi
Since Degrassi is a drama, Tearjerkers are a given.