A close second is "My Body is a Cage," seeing all that Adam went through and how difficult it is for a transgender person.
Time Stands Still.
After Alli loses her virginity, and they show her sitting alone in her ridiculously girly kiddy bedroom, being kissed goodnight by her mom, and making it all too clear that she was not ready for this.
JT's service at the school.
Especially, especially seeing Liberty finally break down over his death.
Jane Says.
Emma's real father.
Liberty giving up her baby.
Clare being sexually harassed by Asher.
Rick being bullied.
KC leaving at the end of "Rusty Cage".
Campbell's suicide and the characters' reactions to it in the episode "Bittersweet Symphony"
Sean breaking down in front of his parents because he killed Rick.
Craig's abuse storyline in "When Doves Cry," and then its conclusion in "Tears Are Not Enough"
Maya finally breaking down after Campbell's suicide towards the end of "Zombie"
Darcy realizing she was raped and the fallout from it, especially in "Live to Tell"
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