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Tear Jerker: You Can Play This
Iron Liz once showed up on JDub's livestream to ask for personal and professional advice. She began talking about her depression and panic attacks, and confessed that she tried to kill herself on her eighteenth birthday. Justin then calmly (and almost casually) admitted that he'd tried it, too.
The discussion also prompted a number of people in the chat to come forward with stories of their own struggles with depression and/or suicide attempts. It's a lot more common than you'd think.
The trailer for the third anniversary special of You Can Play This. "This is the story of how I died..."