XIII, of course, has the sacrifice of Ash Crimson. Elisabeth's reaction to his erasure from time followed by the credits montage of his youth as any traces of his existence (save for his headband) are erased is pretty hard stuff to take without sorrow. Double when the credits also include a certain poem by Robert Browning, which finishes like this:
"God's up in his Heave, all's right with the world"
Even worse in the end of the VERY spoileriffic "long version" of the OP: Evil Ash turns to the screen, smiles sadly and whispers something as he disappears... then the scene changes and we see who is he actually talking to: Elisabeth, who is on her knees in a flower field not unlike the one seen in their childhood photos from her team's ending. She tearfully tries to reach for Ash, and when he's fully gone she breaks down sobbing as a petal-filled wind blows around her... and the infamous Door closes.