This is based on opinion. Please don't list it on a work's trope example list.
Tear Jerker / Star Ocean: Till the End of Time
Ameena and Dion's deaths, the two having been friends for so long and having not seen each other in years with her wish to see him before her illness claims her. Fayt manages to bring the two together for the first time And him vowing that he would survive the battle for her only to be fatally wounded during it. And after he dies, Fayt on the verge of tears claims to her that it's all his fault that this happened only to get no answer and when he looks at her sees that she is dead as well the two dying moments apart from each other. It is then followed by Fayt screaming, "NO!!!!!!!!!".