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Tear Jerker: Splatterhouse
In the end of the fifth stage of the original Splatterhouse from 1988, Rick's beloved Jennifer (roughly) uttered the words "Help. I'm dying.", and then mutates into a hideous clawed beast. It crackles an insidious laughter before fighting Rick. During the fight, Jennifer reverts to her normal self and begging Rick to save her before the monster could take over. After the battle, Jennifer unfortunately dies in Rick's arms.