King Cerus having to cast away Princess Ceilia, for the sake of everyone involved (since Ceilia is a living Nirvana shard, she tends to attract a lot of attention, and not of the good kind). Unfortunately, in order to get her to leave, he needs to say some very mean things to her...
In Crossroads 3:
The treatment Nilhem inflicts on Yuro and Tiffany in his prison for sub-humans.
The same Nilhem also massacres an organization of rebels who were trying to free those prisoners, and turns their leader into a monster which the group has to kill. Infuriatingly enough, he himself escapes.