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Tear Jerker: Neverwinter Nights 2
Shandra Jerro's brutal, torturous death at the hands of her own grandfather. 'Nuff said.
Neeshka in the betrayal scene of Neverwinter Nights 2. This troper isn't sure which version is the most tear-inducing: the one where she turns on you because you've neglected her, the one where she's forced to turn on you, screaming out tearful apologies all the while, or the one where she manages to break through the control to join the first person to ever show her kindness - you.
Bishop's eventual fate. Despite all his bravado about it, it's pretty clear that he's terrified by the thought of being essentially erased from existence.
When Neeshka comes to visit you before the trial, she'll offer to cheat by rubbing acid on Lorne's weapons and armor. It doesn't really matter how Lawful you are: you will let her do it, because the alternative is hearing her say the following in the voice of a child who's been told their drawing isn't good enough to go on the fridge:
Neeshka: All right. I mean, I only had to steal the acid out of Sand's shop and avoid his wards, but if you don't need it, you don't need it. Or me.