The scene where Laval is leaving in episode 17 does this almost too well. First you see Gorzan, who is obviously saddened, but not too bad, then Bladvic, who is his normal sleepy self, and Rogon seems far too cheery for the occasion. Then he comes to the bottom of the steps, where Eris awaits. She's almost in tears, and very clearly heartbroken. The song horizon, which has playing the background, suddenly gets vocals, and the scene from then on makes you want to cry.
That scene in episode 20 will leave you crying abit.