Ralph: I began teasing my prey... talking to her... Next thing we knew, we were secretly in love...and expecting! Corrie: She died giving birth to me? Ralph: (sobbing) I HAVEN'T BEEN ABLE TO HUNT A THING SINCE!
The fight between Rudy and Bruno after Bruno comes out as trans-diet. The fight sequence has no dialogue, and each panel is half dedicated to the fight, with the other half showing their first meeting as babies and their decision to be friends forever. The final panel delivers a punchline, but it's heartbreaking nonetheless.
Put it in a real world context with the implications, it becomes much worse.