- James Haggard's character development as he comes to terms with his pansexuality. Having been raised in a conservative home, and forced into becoming a military man, James' troubles coping with who he is has won the show multiple awards.
- Jeffrey's death. Just Jeffrey's death.
- Patricia Taylor dying in Lily's arms in "Mother's Day", considered one of the most emotional episodes of IS.
- Camilla Sea succumbing to the Deviant Strain. Her body begins to glow and pulsate as the Inspector can only watch powerless.
Camilla Sea: Oh God, it's happening, Inspector. I can feel it, I can feel everything. I am slowly dying!
'The Inspector: I'm so sorry Camilla, I—-there's nothing I can do.
Camilla Sea: (nearing hysterics) It's not fair Inspector, me and Reginald.. I saw our wedding, I saw our children, this isn't possible! How...?
The Inspector: The Time Deviants are
walking Temporal Paradoxes. They are the impossible made possible. The past becomes an unreliable memory. The present, a fluid yesterday and the future, a constellation of chaos.
Camilla Sea: When you see Reggie (tears begin to fall) lie to him. Tell him his Scottish Princess was brave. Lie to him Inspector...Promise me. Tell him I wasn't afraid; tell him that.
The Inspector: Brave heart girl, you are not alone.
The Inspector can only watch in horror and sorrow as
Camilla Sea explodes into
Trans Dimensional Morphic energy leading to her new more alien
Time Deviant form.