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Tear Jerker: Fables
A small and touching one - the death the Mouse Police Rex and his partner's reaction
Tear Jerker: The Last Castle, particularly the ending. Also, the funeral for those who fell in the Battle of Fabletown, against the wooden soldiers.
After Blue's funeral, Fly and Pinnochio are chatting. Upon a reread, this Troper realized Pinnochio was carrying Blue's horn and promptly started crying.
North giving an unconscious Bigby a fatherly kiss before leaving to sacrifice himself in order to dispose of Mister Dark. It's even worse when you remember how Bigby had always hated his father for leaving his mother, and even repeteadly tried to kill him, and yet North had kept on loving his son, to the point of giving him that final affectionate gesture.
Issue #118 reveals the origin of all of the toys in the land of Discardia, through which Therese is now considered queen. They were all indirectly responsible for the deaths of the children they belonged to. And Therese is forced to listen to how some of them wound up there. At least three choking victims, an infection from a cut, death by lead based paint, and a Mr. Mega Truck relates "blunt force trauma".
And then the following Heroic Sacrifice by Dare. It really hits hit home when right before sacrificing himself, he cries and asks why he has to die when he's still just a kid, who never got to do anything yet before finally relenting and asking if anyone will at least know that he did the right thing.
Snow finally meeting her seventh child, Ghost, after all the people he accidentally killed. What makes it even more tearjearking is that he's still so young, and every line of his emphasizes this (with him apologizing for being bad).
When Snow and Bigby finally get married. They were happy tears.
In 1001 Nights of Snowfall with the story of Flycatcher and the story of his dead wife.