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Tear Jerker: Continuum
The time travellers who were flung to the "wrong" point in time and spent years living as temporal fishes out of water with nobody to relate to. Particularly so in the case of Kiera's partner, who arrived in 1975. Imagine being sent back to the 1970s from 2013, never mind 2077. The worst part is that she's suffering from severe Alzheimer's, which was cured in her original time.
Kiera dealing with the loss of her son in "Second Opinion".
Kellog's breakdown when Maddie, his supposed grandmother dies in front of him.
Especially after the reveal that his sister was killed in a similar manner.