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Tear Jerker: Cloud Atlas
From the film
Sixsmith walking through the door literally seconds after his boyfriend commits suicide. Foregone Conclusion, sure, but it's the way he clutches him in his arms, the utter pain on his face, and the realization that he is soon going to discover the suicide note, whereupon he will find out that they were mere feet apart the entire time at the Scott Monument.
Sonmi clutching her chest while crying, when she is told that Hae Joo is dead, as if she is feeling emotional pain unlike anything she's felt before, having been kept in such a monotonous and unengaging cycle her whole life. It was just such a broken and sad look. Luckily, Hae-Joo is alive, kicks some ass and saves Sonmi.
Then when she meets her end. She meets it with dignity, however and even while she tears up, shegoes out with a smile.
Zachry's reaction when he finds the bloodied corpse of his sister, throwing himself to the ground and tearfully kissing and touching her face.
The entire ending counts as one, but in a happy tears way. Some lives end, other goes on but life always remains constant, no matter where we are. And if we are separated from the ones we love, in some way shape or form, we'll meet together again.
From the book
Frobisher visits a graveyard of soldiers hoping to lay flowers on his brother's grave, but can't find it. His letter attempts to keep up his cavalier tone, but he notes that he'd foolishly hoped he'd somehow just know which grave held him, wonders if his brother had liked men too, and remembers with resentment how their parents had said "You should be like your brother!" in increasingly poisonous ways. When the car he's in strikes a pheasant on the way back he's profoundly horrified by how it screams like a child, goes out of his way to give it a Mercy Kill, and is shaken up by the whole experience.