Tear Jerker / Brandy & Mr. Whiskers

  • Ed's reaction to Brandy cutting him off from the team in the episode The Big Game.
    • Pretty much any moment that makes Ed into a Woobie qualifies as this.
  • Rip Van Whiskers. Well, Whiskers is revealed to have not touched any poison after all so it all ended out fine, but it's still pretty depressing nonetheless.