- The town Street Urchin, who has been harassing James and other town-folk, brings his dog in with distemper. While James desperately tries to cure the dog, the boy becomes a model citizen and even takes on odd jobs to pay for the care. The TV version is hard enough to sit through with a dry eye, but the book makes it worse by suggesting that his dog was the only thing keeping the boy from a very bad end.
- A married couple are planning to split up, but stay together because their dog is dying. If you thought the experience would bring them together and convince them to give it another try, well....
Tear Jerker / All Creatures Great and Small
There are many, since the series never whitewashes the fact that animals often die or have to be put down. But some are especially notable.