Alex Albrecht's show 4Points on the Nerdist network can be seen as a successor to Diggnation as it more or less picks up on the same format but with an additional two hosts.
New York Magician: Compare the writer's earlier Ethereal Park Ethereal series, which also features magical elements in an otherwise normal New York, along with some Urban Exploration influence. However, the protagonists are very different; Michel is an rich man experienced at all this magic stuff, while the narrator of PE is a broke homeless guy who can't remember his name or past and has no real idea what's going on.
The Whateley Universe is the spiritual successor to the 'Of Masks and Marvels' universe. The author of the latter is one of the key creators and main authors of the former, and they are both superhero universes with transgender protagonists. The main character and main superhero team of the Masks and Marvels world even have expies in side characters at Whateley Academy.
Richard Michael Alvarez, creator of Stupid Mario Brothers, announced that a spiritual successor to SMB called That Stupid Video Game Show. It will feature generally the same characters as SMB but will not have an overarching storyline like its predecessor. Each episode will be self-contained.
TV Trash could be seen as this to Benthelooney's 2009-2011 run of rants, because of The Rowdy Reviewer's characterization, the way he voices his opinions (Fair and less harsh when compared to other caustic critics), less focus on jokes, and more focus on the subject at hand with an occasional joke thrown into the picture. (Especially so, since Benthelooney took a different direction to the way he was before cancellation, when his rants restarted production.)
Crossing with Music, Buffalaxes are the spiritual successor to Animutation. Both runs on Mondegreens, but while Animutation creators create trippy animation to go with what they mondegreened, Buffalaxes tend to be more straightforward and use the real music video wholesale, with the humor coming from over-the-top expletive-laden mondegreens of the song lyrics instead being shown as the song's subtitles. Buffalaxes started surfacing a few years after the animutation craze has died down.
Crossed was a series of short video by Karim Debbache where he reviewed movies based on — or talking about — video games. The series ended after the 28 episodes negotiated with JeuxVidéo.com, the website which hosted his videos. After negotiations with the website and other potential partners failed, Karim launched in 2016 a new, crowdfunded show called Chroma. The new show doesn't just have a similar title and subject as Crossed but also the same length and format, the same humor, Karim's friends Gilles and Jeremy coming back, and generally feels like a season of Crossed that doesn't focus on videogames.
The Dick Show is considered by many fans to be this to The Biggest Problem in the Universe.
Discussed in SF Debris' review of Star Trek: Nemesis. Like many Trekkies, Chuck Sonnenberg feels that a major problem with Nemesis is that it tried way too hard to be a Spiritual Successor to Star Trek II: The Wrath of Khan, a film often cited as the best of the Star Trek movies; it features a genetically modified human villain who's framed as the Evil Counterpart of the heroic Captain, an experimental doomsday weapon figures into the plot, it climaxes with a one-on-one starship battle, and it even ends with Data pulling a Heroic Sacrifice to save the crew à la Spock. But as Sonnenberg argues, the producers didn't realize that they had already unintentionally made a much better Spiritual Successor to The Wrath of Khan with Star Trek: First Contact. Both films are follow-ups to classic episodes of the TV show ("Space Seed" and "The Best of Both Worlds", respectively) that feature Kirk and Picard attempting to come to grips with their Fatal Flaw while battling their most personal enemy, and they feature them confronting the legacy of the brutal 21st century in the personage of Khan Noonien Singh and Dr. Zephram Cochrane. note Both are important in-universe historical figures who cross paths with the crew of the Enterprise; one is an infamous tyrant who waged the bloody Eugenics Wars based on notions of genetic superiority, the other is a revered scientist who led mankind into a new era of peace in the wake of the Third World War. Khan meets the crew after being locked in cryogenic stasis for three centuries, while the crew meets Cochrane after traveling through a time warp into the 21st century.