Something Completely Different: Comic Books
- Y: The Last Man has two issues that focus on a theatre group trying to make important work about the post-Gendercide world. Their first effort is not received well. Later they try films and comics. Also, a supermodel whose profession is obsolete and is now clearing bodies (a minor character from early in the story) gets a issue later on.
- Peter David, fed up with the Wolverine Publicity that drives the X-Men franchise, once wrote an issue in his X-Factor featuring none of the usual cast, instead focusing on popular characters like Wolverine and Cable.
- The classic Uncanny X-Men story Kitty's Fairy Tale. The cover even featured Kitty Pryde announcing, "And now for something completely different!"
- Strangers in Paradise had a Superhero Episode, as well as a send-up of Xena: Warrior Princess, after it was pointed out by fans that Francine and Katchoo resembled Xena and Gabrielle. (Katchoo was less than thrilled to wind up as Gabrielle.)
- Adam Warren started the last run of volume 2 of Genął by doing a whole issue in the style of VH-1's Behind the Music, featuring each character's fake demise in ironic ways.
- Issue #34 in both series of Marvel's "What If?...?" were all-humor issues.
- The Mighty Thor #356 makes a pause in the dramatic aftermath of the destructive Surtur Saga, and features Hercules instead, narrating a completely made-up fight against Thor.
- The shift from the Brian Michael Bendis Era Avengers to the Jonathan Hickman Era is a very noticeable example. From the more accessible, Bendis-voice-filled Avengers to the more high-concept, sci-fi Hickman Avengers.
- After Joss Whedon took over Runaways, he veered sharply away from the usual storyline of the Runaways dealing with some Monster of the Week by sending them back in time to 1907, where Victor falls in love with a local girl, Chase and Nico discover that an earlier version of the Pride is trying to start a gang war, and Karolina and Molly try to rescue a young girl stuck in an abusive marriage to a much older man.