Given Itokazu-sensei's codename, Ender, it might be a reference to another Orson.
Further confusing the issue is the stated item in Episode 11 that the Orsonians can (and have) taken away a entire race's ability to think if they break galactic law enough times.
Given the amount of TV show references, maybe it's just this Orson.
Eris' assist droids snuck into an airfield under the cover of a cardboard box.
It's something of a trope in anime for there to be a mikannote mandarin orange box with a puppy or kitten in it and a sign that says, "Please take home". In this case, the box said, "Please don't take home."
In episode 2 when breaking Eris out of the military base, Kio's uncle set explosive as distractions. He yells "Ka-BOOM"
Episode 9 pays tribute to Captain Future, a show based on a series of novels by pulp SF author Edmond Hamilton.
After the end credits of Episode 9, Lawry apparently sinks to the bottom of the water in a fashion eerily similar to a certain famous death in Final Fantasy VII.
In Episode 10, the church bell of the black and white film "espousing the virtues of kindness and generosity" is the final shot of the heartwarming Frank Capra Christmas classic It's A Wonderful Life. The directors show their love for classics by having Chaika openly saying "Oh, no matter how many times you see it, this is still a lovely, lovely film."
There's a sight-gag in Episode 4 with a couple of black cat assistdroids delivering a package to Aoi - a shout-out to the well-known Kuroneko (Black Cat) Transport Service, a.k.a. Yamato Transport.
The Dogisian Assistroids all look like Mousers but with arms and dog ears.
Tilsonite is a fictional meteoric mineral appearing in Ultra Q, the first installment of the Ultra Series. Tektites, by the way, are real glassy rocks of meteoric origin.