- In the pilot, they reference Beauty and the Beast with "Beauty and King Dork" - complete with CGI ballroom.
- Turns out Vlada and his son are from Pottsylvania.
- From "Frankie and Ellie Get Lost," Franklin acting like Curly after first drinking alcohol which made him into his present stupid state, with Albert Einstein and Ted Kennedy acting like Larry and Moe respectively.
- Prince Charles sounds like one of the Gumbies, while Queen Elizabeth sounds like the troupe's usual Cross-Dressing Voices, particularly the "women" in the Spam sketch.
- One of the more Stealth Pun Shout Outs of the show is Alice's sister Miranda using venetian blinds for her dress, a reference to the famous Gone with the Wind spoof from The Carol Burnett Show.
- The Crying Game: In the season 1 episode "A Little Deb Will Do Ya", Jay meets the girl of his dreams, but she has a secret - down there. Turns out she's wearing the bottom half of her work clothes - Humphrey the Hippo.
- A reviewer's face melting off and reducing him to a skeleton (after Roger Ebert shows him a clip of a bad movie) is a reference to Raiders of the Lost Ark.
- The episode "Miserable" is an obvious parody of Misery. The female projectionist even resembles Kathy Bates.
- Penultimate episode "Dukerella" is a cross between Cinderella and A Streetcar Named Desire.
- Arthur. A drunken Arthur Bach (Dudley Moore) appears in several episodes.
- The penguin pilot's "Waakwakwakwak" speech imitates Burgess Meredith's laugh as, yup, The Penguin from the '60s Batman show.
- The ending of "Frankie and Ellie Get Lost" has a closing shot of Gilligan's Island, complete with theme song.
- Franklin dressed up as El Kabong is a reference to Quick Draw McGraw.
- Elenor saying "No more wire hangers!" is a direct reference to the film Mommie Dearest.
- Alice's Take That to Tim Allen is funnier when you consider The Critic had preceded his show before ABC dumped it.
Alice: Listen, honey, I've known men like Duke all my life. There was this one boy back in college – dealt drugs, went to jail – yet today he's the star of Home Improvement.
- "A Pig-Boy & His Dog" concludes with "That's all, folks!"
- The "Rosebud Frozen Peas" commercial is a direct spoof of the Frozen Peas blooper tape.
- In the episode "Marty's First Date", the intermission music from Ms. Pac-Man plays after Jay gets a whiff of some fried bananas. The song is omitted in the DVD release.
- In "Dukerella", Jay and Alice dress up as Homer and Marge Simpson, respectively. The same episode has Elenor as Queen Grimhilde and Franklin dressing up as The Mask.
- Jeremy mentions his first role was in an Australian movie called Kegger Party At Hanging Rock.
- When Jay goes crazy from trying to think of new material, all he's typed is "All work and no play makes Jay a very dull boy." over and over again.
- Shout Out To Shakespeare: Keanu Reeves in The Merchant of Venice:
Shylock: Hath not a dude eyes? If you prick us, do we not get bummed? If we eat bad guacamole, do we not blow chunks?