Happens regularly on Pearls Before Swine in Rat's stories about "Angry Bob". In a typical example, Angry Bob decides to go to a bar to socialize, and quickly strike up a romantic rapport with a beautiful woman. They begin kissing in her car, only for Bob to get caught by the woman's UFC husband and die horrifically.
From Calvin and Hobbes, Calvin finds◊ an injured baby raccoon and tries to help it. He fails, and the raccoon dies. The real point of the story was showing how Calvin would cope with death.