- Attack on Titan: The Flash's mother Kazuko Suema was killed when man-eating giants broke into the fortress city. In order to avenge her death, Flash joins the military with Carrie and Takato.
- Bakugan: After a rain of cards from the sky, Sheldon Cooper uses them to create a game with other kids and forms a team with his friends Angol Mois, Omochao, Lily, Cilan and Sana. One day, the kids bond with some of the orb characters coning from the cards, and Sheldon gets Clark Triton as his partner. Also a menace appears, coming from Sousuke Sagara and Escargoon.
- Bakugan: New Vestroia: After some time, Sheldon, Cilan and Omochao arrive in the dimension the Bakugan came from, and join Yatterman-2, Blurr and Bat-Mite into fighting the evil king Kaos and his servants, like Sai, Nathan Drake, Ichigo, Gingka and War Machine.
- Bakugan: Gundalian Invaders: Later, Is found a way to make people fight with their Bakugan in a online-like way. Sheldon, Omochao and Cilan meet Buggy the Clown, Senri and Twilight Sparkle. The last one comes from another world, under attack by evil invaders, and asks the other guys to help her.
- Black Lagoon: Kovu, Fionna, Dexter, and their boss 8 team up against terrorism and Neo-Nazis. Minh works for the Russian Mafiya. Lil DeVille is a combat maid.
- Bobobo-bo Bo-bobo: Garfield, Nermal, Snow White, Gretchen, Slade, and Dengaku Man fight an evil empire.
- Chrono Crusade: Bat and Mimmy are demon hunters. Keesha and Dorothy Ann later join them. Mimmy's missing brother is Sasuke Uchiha.
- Code Geass: Aladdin seeks to make a better Japan for Little Suzy after gaining powers from Mikey. This is complicated by the appearance of Aladdin's old friend George Michael on the other side.
- Cowboy Bebop: Evan Baxter, Nixon's head, Carrie Bradshaw, and Wubbzy are outer-space bounty hunters looking for Evan's girlfriend Wendy and Evan's greatest enemy Jerry Maguire.
- Death Note: Otto Osworth finds a mysterious notebook dropped by Aslan that causes people to die if their name is written in it. Mumble, the world's greatest detective, tries to stop him. Chris Thorndyke eventually learns the truth about Otto.
- Detective Conan: Yusuke Urameshi is the world's greatest teenage detective… until he is drugged by Megatron and Frieza and becomes Akito Hayama. Akito moves in with his ex-girlfriend Gwen and her detective father Professor Layton. He also joins a team of kid detectives with Rambamboo, Brock, Chopper, and Sari Sumdac.
- Digimon Adventure: During summer camp, Maya Ibuki, Mutsumi, TJ, Shippo, Spider-Man, Lily Potter and Mandy arrive in Digiworld and meet their Digimon partners Dr. Manhattan, Mother Gothel, Prowl, Lelouch, Viral, Pretty Sammy and Seth Cohen, which help them into fighting evil Digimon. Later Ming Ming and her Digimon Poisonny join the group.
- Digimon Adventure 02: Three years later, Shere Khan (who was Light Yagami in the movie), the first Linka, and Chowder, along with their Digimon Pat, Copperhead and Klaus, fight with Mandy and Ming Ming against evil Black Star and his Digimon Stewie.
- Digimon Tamers: Ray Ray, Hyatt and Mark Evans meet one day their Digimon partners, respectively Jazz, Spider-Woman and Koizumi.
- Digimon Frontier: One day, Phil, Gwen Stacy, Naruto, Nani and Gwen Tennyson are sent to Digiworld and given the power to transform into The Phantom Renegade (later Mr.EAD), Cleopatra, Silverbolt, Jake and Hot Shot.
- Digimon Xros Wars: Joffrey Baratheon, Maka Albarn and Marco Polo are warped to Digiworld to help Simon become the King of Digiworld by defeating the evil Bagra Army led by Daddy Pig. Ryoko Asakura and Jacob Black, along with their Digimon Aang, Finn and Zorori are fighting the army too. After Joffrey, Jacob and Ryoko join their armies, Musa becomes Ryoko's new partner.
- Digimon Xros Wars: The Young Hunters Leaping Through Time: Years later, Joffrey, Ryoko's brother Ox Ford and Harry Potter (whose partner is Daring Charming) fight evil Digimon messing around in the human world. In the final battle, Maya, Spider-Man, Shere Khan, Black Star (now Sheldon Cooper), Ray Ray, Phil (now someone else), Hot Shot and Mike join forces. Viral is now Kevin Levin.
- Doraemon: (older episodes on RAI) Marge Simpson is Blurr's robotic cat.
- Dragon Ball: Lambo (who grows up becoming Tokkori) follows Nami in search of the Dragon Balls. Later he's trained by Squidward with his friend Tails (Later growing up into Blackarachnia, and then into the Computer Club president) and fights Dinobot and his son Barricade.
- (original dub) Panda follows Nicole Watterson in search of the Dragon Balls. Panda is later trained by DVD!Pumbaa.
- Dragon Ball Z: Tokkori has married Sailor Moon and had a son named Yoru (who grows up to be Michelangelo). One day he meets Tamama, who says he's his brother and also a Saiyan. Later Tokkori fights evil Saiyans Peppermint Larry and Starscream, then Rio, Ninjor and finally the Joker.
- Dragon Ball GT: Tokkori makes a wish to the Dragon Balls that turns him back into Lambo. He then chases the balls into space with his niece Rainbow Dash and Masquerade, Starscream and Nami's son.
- Dragon Ball Resurrection F: Nicolas Cage makes a wish to the Dragon Balls that brings Mowgli back to life. Can
- Eureka Seven: King is an average teen who lives with his grandpa Principal Pixiefrog after his sister Sidney Prescott goes missing while looking for their father. One day King meets the mysterious pilot Unikitty and falls in love with her.
- Excel Saga: Tails and Amu are agents of Across, working for R.J, who plans to take over a city.
- Fairy Tail: Dora wants to join a magic guild. One day she meets Joffrey Baratheon and his flying cat Mossy. Once Dora joins Joffrey's guild, she also teams up with Shinji Ikari and Lapis Lazuli. The guildmaster is Gonzo, and other members include barmaid Gwen Stacy, the manly Ziggy, and party girl Helga. Gonzo's grandson Naxus is the leader of Patamon, Bixlow, and Sally Botsford. Gretchen Wieners and Rick Grimes later join Gonzo's guild.
- FLCL: Kyon is an average guy who lives with his friends Miles and Mami Tomoe. One day Kim Bauer hits Kyon on the head with a guitar, causing a robot to grow on his forehead.
- Fullmetal Alchemist: Mr. Mackey and his sister Applejack go on a quest to get their bodies back by using a mysterious stone. They are followed by Starscream. Also, they eventually run into their father Captain Hero.
- Full Metal Panic!: Sgt. Scarecrow is told to protect the high school student Revy with help from Lelouch and Miri. Hermione Granger is their submarine captain, and they often fight Cyborg.
- Gaiking: Legend of Daiku Maryu: Rigby searches for his missing father, remembering the giant monster that attacked them both five years ago. After Chichi summons Rigby to defeat the monster with a giant robot, Rigby meets a metal dragon and its crew members.
- Hamtaro: Harley Quinn, Arcee's hamster, runs away from his cage everyday to meet his friends Zoro, Wreck-Gar, Hazuki, Menma, Mac, Aquaman, Barbie, Luke Triton, Lambo, Conan Edogawa, Serenity, Ash Ketchum, Hinata and Gotenks. Zoro's owner is Sailor Mars.
- Discord is a dark wizard.
- Hunter × Hunter: (Rome) Aang, Naruto, Sam Witwicky, and Spike Spiegel try to get their Hunter licenses.
- InuYasha: (season 1/Final Act) Yakko Warner, a half-demon living in the Sengoku Era, falls in love with T-AI]], a high school student who finds herself transported back into the past.
- Kiki's Delivery Service: Azula is a preteen witch, who, after her 13th birthday, is on her quest for independence. Along the way, she meets Cody.
- Kirby of the Stars: Chibi-Usa and Odd find the title character after he comes to Earth. Plankton is king, and Batman sometimes helps Kirby.
- The Melancholy Of Haruhi Suzumiya: Daphne is bored of normal people, so she founds the SOS Brigade with Frodo. Yoko, Revy and Terriermon later join them.
- Mirumo De Pon: Linus Van Pelt is a fairy prince who escapes in the human world because he doesn't want to marry Gaz, and decides to help Thea to declare her love to Otto Rocket... but Gaz comes too, becoming Otto's companion. Linus's enemy Nico Robin comes and helps Aki into getting Otto's love before Thea does. Then Russell comes by, and he's in love with Thea. He's helped by Dexter, Linus's little brother.
- My Neighbor Totoro: Toph and Lilo have adventures in the countryside after moving in with their dad Knuckles. Lumiere is the mysterious title character.
- Naruto: Beast Boy, Ikuto and Lina Inverse are three ninjas trained by Rattrap (later Roy Mustang). Ikuto later joins Superman to seek revenge on Ikuto's brother, who is also Superman. Lina is trained by Maddie Fenton, and Beast Boy leaves the village to be trained by Charles Xavier.
- Neon Genesis Evangelion: Goku, Lil (who was Daphne as a child), and Kim Possible are teenagers forced by Goku's father Jafar to battle "Angels" while under the command of Batgirl and Betty Rubble.
- Ojamajo Doremi: Clumsy Blackarachnia becomes a witch's apprentice after learning that Kid Goku is a witch. Blackarachnia's best friends, girl genius Bijou and tomboy May, later join her
- One Piece: Hyoga (later Fox McCloud) is a pirate made of rubber searching for a treasure with his crew: swordsman Keroro, navigator Twilight Sparkle, sniper Boyakki, chef Bulkhead, doctor Dexter, archaeologist Kid Goku, shipwright King Dedede and Orko.
- Pokémon: Fungus wants to be a Pokémon master. He travels with Rei Hino and Max, and fights against Nami, Arthur, and Spider-Man (who later becomes Doraemon). During the Orange Island travel, Max stays behind and is replaced by Jaden. Upon Max's return, he has become Hunk.
- (season 1 redub) Fungus travels the Kanto region with Carly and Hunk. They are followed by Nami, Arthur and Doraemon.
- Pokémon Advanced: Fungus and Hunk travel in the Hoenn region with Aiko and Rainbow Dash.
- Pokémon Diamond & Pearl: Fungus and Hunk travel in the Sinnoh region with Sari (who later turns into Kaho).
- Pokémon Black & White: Fungus arrives in the Unova region and travels with Irma and Stan Marsh.
- Pokémon XY: Fungus, Pikachu, Princess Luna and Dipper Pines and Chloe explore the Kalos region.
- Pokémon Origins: Spyke and Kaito start their journey to complete the Pokédex as asked from Kaito's grandpa Cheetor. Megatron leads Team Rocket, and Crow Hogan is the Pewter City gym leader.
- Ponyo on the Cliff by the Sea: Morpheus finds out that his daughter Anais wants to become human so she may befriend Bruno. Bruno's mom Gloria works at a retirement home where Guinan lives, and his dad the Crimson Chin is off at sea.
- Puella Magi Madoka Magica: April O'Neil recieves from Mira the proposal of turning into a Magical Girl. Lindsay tries to stop her from accepting the offer. Silver Spoon, Astrid and Luna Lovegood already accepted.
- Ranma ˝: Chuck Coleman (later Daniel-San) is an expert martial artist who turns into Blossom (later Susie Carmichael) when splashed with water.
- Sailor Moon: Penny learns that she's a Magical Girl. She then joins her other team members, including Batgirl, Sabrina, Pinkie Pie, Montana Max, and Penny's future daughter, Beth Oblong. Batman is Penny's boyfriend.
- In the first film "Promise of the Rose", Penny is now the first Kagome. She, along with Montana Max, Pinkie Pie, Sabrina, and Batgirl, who are now Giselle, Sydney Prosser, Patty Peterson and Johanna Mason, respectively, must stop Howl from taking the enchanted flower. Beth Oblong (now Hermione) is left behind with Kagome's cat Mulan and Giselle's cat Joey Wheeler.
- Saint Seiya: Swindle is the Saint of the Pegasus constellation, and protects the embodiment of Athena Surprise along with Edd, Kurama, Batman and Mario.
- The Seven Deadly Sins: The Holy Knights have taken over the kingdom of Leones. In order to save her kingdom, Brittany S. Pierce must gather a team based on the Biblical sins: Ginta, Carrie, Tobias, Dorkus, Mrs. Cramp, SheZow, and Escanor. Some of the Holy Knights are Reptil, Matt, Kyle Reese (who is really Mordecai), Abraham Lincoln, Mr. Conductor, Santana Lopez, Billy Nolan, Cure Happy, and Fred.
- Sgt. Frog: Superman tries to conquer Earth, but he ends in Misty and Emporio Ivankov's house, where he starts to live, doing house cleaning and building Gundam model kits. Later the other members of his platoon (Blitzwing, Link, Alpha 5 and Kaiba) arrive.
- Shaman King: Kero is a kid interested in ghosts. One day, he meets Aldous Snow, a shaman who is engaged to Bulma. With Aldous and his spirit partner Captain Knuckles, Kero also goes on adventures with Hunk and Green Arrow.
- Shugo Chara!: Namu fights The Heartless with the powers of Batgirl, Harley Quinn and Gilda. Namu crushes on Sasuke Uchiha, but Namu's rival Tak doesn't want to talk about this. Namu is part of her school's council with Aang, Jack Darby, Bouquet and Rogue.
- Smile Pretty Cure!: An evil emperor has ordered an attack on the kingdom of Jubiland. After using the last of her energy to seal the emperor away, Queen Euphoria sends Goomo to recruit a team of Magical Girls: Queen Leila, Maeby, Kelly, Yoriko, and Natalie Bouchard. Goomo's brother is the Roman Kid Goku.
- Sonic X: Kyle, a very fast hedgehog, fights the evil Bender with his friends Circuit, Courage the Cowardly Dog, Near, and Timmy Turner.
- Soul Eater: Kyoko Sakura, Billy and Gideon Gordon Graves are students at Norm the Genie's school. Norm is Gideon's father, and Kyoko's weapon is Edward Cullen.
- Spirited Away: After her parents Rex and Nanny McPhee are turned into pigs, Patsey recruits the help of Sister Mary Clarence, Prince Caspian, and Granny.
- Stitch!: Alien experiment Booster Gold lands on a Japanese island, becoming Bijou's best friend. He's joined by Franky and Usopp.
- Sword Art Online: Fanboy is a beta tester trapped inside Jiraiya's virtual universe; Jiraiya disguises himself as Optimus Prime. Fanboy then teams up with Amethyst, Pearl, and Clyde in order to fight for their lives.
- Tengen Toppa Gurren Lagann: Shu (who matures into Sasuke Uchiha, then into Prince Charming) makes an alliance with Iron Man, Freakazoid! and Knives Chau to fight the Gunmen led by Jet Black. Shu falls in love with Strawberry Shortcake.
- Time Bokan: Shin Chan and Shinobu travel in time searching for Shinobu's grandpa. Yzma, a self-destructing tape and Hong Kong Phooey follow them, searching for explosive diamonds to use as a valuable source.
- Toradora!: Mordecai and Poof are high school students in love. Don Patch is also interested in Mordecai.
- Transformers Armada: Autobots led by Lord Shen fight Decepticons led by Fred while collecting Minicons.
- Transformers Energon: A few years later, Grim resurrects Fred and other Decepticons, like Timmy's dad and He-Man. Shen and the Autobots have to fight them again.
- Transformers Cybertron: Ancient Autobot Aggregor calls Ashura and the Autobots to retrieve the Cyber Planet Keys. Fred and his Decepticons are searching for them too. At the end, fellow Decepticon Chef Hatchet takes over.
- Transformers: Robots in Disguise: Autobots led by Lucius Malfoy with other guys like Cosmo, Daredevil, Big and Lucius' brother Ned Flanders fight Predacons like Michael Knight, Kamina and Wakko Warner, along with Decepticons like Owen, Major Monogram and Kowalski.
- Yatterman: Richie Cunningham (later Spock) and his girlfriend Arusu (later The Great Will of the Macrocosm) fight against Daphne Blake (later Roseanne), Shin and Bazuki to get the Dokuro Stone.
- Yes! Pretty Cure 5: Distracted by a butterfly, Raven runs into Beast Boy. With the power of dreams, she becomes a Magical Girl. With her best friend Maggie Pesky, Penny, Velma, and Gwen Tennyson; Raven must find 55 pixies to restore Beast Boy, Rei Ayanami, and Spider-Man's homeland.
- Yes! Precure 5 GO!GO!: The team is joined by Speedy Gonzales and Rei.
- Yu-Gi-Oh!: Rock Lee plays card games and has a split personality. His best friends are Donkey Kong, Ichigo and Bucky O'Hare and Sanji is his rival.
- Yu-Gi-Oh! GX: Dante is the new student at the Duel Academy. Some of his friends are Lyserg, adult Simon, Guy Gardner, Wheeljack and Sakura.
- Yu-Gi-Oh! 5D's: Braeburn comes to the city of New Domino from the Satellite and discovers himself as one of five predestinates, along with Keroro, Hayato, Jean Grey and Megumi.
- Yu-Gi-Oh! ZEXAL: Young Ezio Auditore helps Blue Beetle to get his memory back finding the 99 Number cards. Sweetie Belle, Doctor Whooves, Little Strongheart, Snails and Benjamin Stilton are Ezio's best friends, while Quicksilver and Raf Esquivel are his rivals. Albeit the real bad guys are Batman, Kaos, Kakashi, Paul and Mac.
- YuYu Hakusho: Bugs Bunny, SpongeBob SquarePants, Neji Hyuga, and Mary Test are hired by Puar to become demon hunters.