- Ai Yori Aoshi: Kakashi and Yukari Takeba meet on a train after many years, and Yukari remembers that she was promised to marry him. Yukari's caretaker, Milly Thompson, wants them to keep their relationship a secret (especially from Kakashi's friends Weda, Hare and Aigis) to preserve her family's reputation.
- Air: Edward Elric journeys from town to town looking for a mysterious girl. Along the way, he meets Asa Shigure, Mio Sakamoto, and Misaki Nakahara.
- Akame ga Kill!: Swordsman Ooyama joins a band of assassins composed of Mako Reizi, Mellisa Mao, Rei Miyamoto, Paulie, Chiyo Mihama and led by Medaka Kurokami.
- AKIRA: Tai and the Black Ranger are two cyber punks in Neo Tokyo. After Yukio Oikawa and his crew inject him with something, Tai discovers he has powers even more awesome than digivolving and uses them to kill Joe.
- Appleseed: Ling Leung is part of a futuristic SWAT team.
- Arrietty: US Version: (video game) Thorn is the boldly inquisitive daughter of the Van Waldenberg siblings who sneaks into Sue Sylvester's mom's house and meets a boy whose dad had a very eventful love life.
- Assassination Classroom: Highschoolers who consist among others of Ruka Urushibara, Panty, Stocking, Asuka, Rin Jimmy Kudo and Accelerator are asked to kill their teacher Usopp before the end of their year or else the world is destroyed.
- Attack on Titan: In a world where the last bastion of humanity is enclosed by walls to fend off man-eating titans, Kirito, Mari Illustrious Makinami, and Yukiteru Amano join the military in order to fight the titans outside the walls. Kirito is driven to kill every titan ever since he saw one kill his mother, Moeka Kiryu.
- Axis Powers Hetalia: Death the Kid, Franky, and Dhalsim unite to become the Axis Powers. They fight the Allied Powers, led by Trunks who controls England, Dororo, Kaede Nagase, and Jimmy Kudo.
- Azumanga Daioh: Nayuki Minase, Izumi Curtis, Ruri Hoshino, Ren Mikihara, Reika Ryuoin, and Pen-Pen go through high school together.
- Baccano!: Three crazy storylines; in the first, Hikaru Hitachiin is inducted into a mafia family and is friends with Syaoran and Lord Montague. He then meets Eve who is working for Tanaka against her will. In the second, Yoite is a Lovable Coward who is on a train with his friend and fellow bootlegger Yuuko, who is also a Mad Bomber. Meanwhile, Dragon and his fiancee, Mokona are plotting a killing spree, Alphonse is a paranoid survivalist, Yuki is in jail and a cult (which includes his daughter, Belarus) is trying to break him out and they all have to fear a monster that's killing them all (actually Kyo Sohma). Finally, Bardroy's gone missing and his little sister is desperately searching for him. And while all of this is going on, Kyouya and Winry are a pair of screwball thieves who carry their antics throughout all the storylines.
- Baka and Test: Summon the Beasts: Class F idiot Kenichi and his fellow students Moka Akashiya, Blair, England, Ciel Phantomhive, and Kaoru try to defeat Class A students Masane Amaha, and Ciel Phantomhive, (and others) in test score based battles in an academy run by Principle Envy and Disciplinary Master Father.
- Bamboo Blade: Young kendo prodigy Yoshika Miyafuji becomes the star player on an all-girl squad coached by Douglas Rosenberg, led by Lenalee Lee, and co-starring Ai Enma, Kaede Fuyou and the sometimes-crazy Nodoka Miyazaki. A rival team is coached by Garland.
- Berserk: Roronoa Zolo is pissed about what Professor Go did to him and Mami Tomoe in the past.
- The Big O: Leeron is a skilled negotiator who's often accompanied by his Robot Buddy Shion Uzuki. He frequently runs afoul of Haruhi Suzumiya.
- Big Windup: Koenma is a very shy and withdrawn baseball player, but Chrono convinces him to come out of his shell.
- Birdy the Mighty: Decode: Space Police officer Kaname Chidori accidentally kills Soul Eater while chasing after an intergalactic criminal, and winds up Sharing a Body with Soul until she can shut down their syndicate, ran by Kirika Yumura. Gray Fullbuster is another member of the syndicate and breaks Kaname's arm, Kyouko Aono is friends with Soul, and Rei Ayanami is interested in Soul. Additionally, Tsukune Aono is a TV producer with Social Darwinist tendencies and Masane Amaha is Soul's sister. In the second season, it's revealed that Kaname was friends with Sanji, who's taking care of Al Elric.
- Black Butler: Kyouya Ohtori is simply one hell of a butler for Lyuze, who is an orphan engaged to marry Asuna. Other staff for Lyuze include Hei, Dandy, and Tsubaki, with Richard Moore occasionally stopping in. In the second season, Nami and an uber-monk are their rivals.
- Black Lagoon: Light Yagami, Gilda, and Venom (and their boss, Nick Fury) form an unlikely team against gangs of terrorists and Neo-Nazis. Dr Holder is a Russian mafiya boss who occasionally hires them.
- Bleach: Lelouch receives Soul Reaper powers from Yuki Nagato in order to protect his family, but she eventually gets captured by Yang Fang Leiden and Jon Arbuckle. With the help of Hinata, who secretly has a crush on him; Largo, his best friend who fights for his sake; and his rival and friend Vexen; he sets out to rescue her and eventually fight against the evil Karasu.
- After some training from Apollo and Faye Valentine (who masquerades in the form of Aoshi Shinomori), Lelouch and company join up with Santa Claus to go rescue Yuki. Along the way, he fights and beats Edward Elric, Jon, Shigemori, and eventually Yang. Shino beats the pants off of Czar Baldy Bald, but loses his powers for his trouble. And Largo can't quite get past The Third Hokage. Afterwards, Karasu betrays the Soul Society with Hamrio Musica and Al-Cid Margrace.
- In the Bount arc, Lelouch's brother Schneizel shows up as a vampire with a chip on his shoulder.
- After Lelouch's father Franky reveals that he's quite badass, Lelouch is conscripted by Ezio Auditore to join his army of half-Hollow hybrids: Reina, Ginko, The Anti-Spiral King, Rachel Alucard, Shin Nohara, and Prince Eccentro.
- Later, Hinata gets kidnapped by Karasu and Lelouch has to go into another world to rescue her with the help of Shino, Largo, Yuki, and Jon. He and his allies go up against Karasu's army, including Willam B. Baxter, Gensai, Lust, Lancer, Dean Venture, Jin Kisaragi, Peter Stillman, Venom, Angemon, and Xemnas. When they get in over their head, Apollo sends them some help in the form of Yang, Czar Baldy Bald, Sakura, and Shigemori.
- Bleach: Memories Of Nobody: After a chance encounter with Kiyal, Lelouch has to stop Excalibur and Save Both Worlds.
- Bleach: The Diamonddust Rebellion: Captain Neji Hyuga has to stop his old friend Johan Liebert.
- In one filler arc, Lelouch is asked by Deidara to protect Tsukasa. Elsewhere, Lieutenant Warrior of Light welcomes his new captain, Bishop Jovis, and the third seat Kittan.
- Bleach: Fade to Black, I Call Your Name: The Soul Society has its memories of Yuki erased by Kenshin Himura and Tohru Honda. The only people who remember her are Lelouch and Axel.
- Zanpakuto Rebellion arc: Yukio Oikawa, at the behest of his master Li Xingke, causes the various zanpakutos - Guile, Cousin Oliver, Viral, the second Shobu Kirifuda, Major Makoto Kusanagi (who's attached to Carl Clover), and others, to materialize and wreak havoc. Yang betrays the Soul Society to join them.
- Bleach: Hell Verse: Lelouch's little sister Gi is dragged into Hell by Harm, so he joins up with Thor to get her back.
- Invading Army Arc: Liquid Snake makes evil clones of everyone in pursuit of his other half.
- Lost Agent Arc: After Lelouch exhausts his powers fighting Karasu, he trains with a group led by King Roland II, which includes Great Britain and Cerebella. But the evil Tygra is afoot, aided by his associate Spock.
- Blood+: After being saved by Itachi, Ashe discovers that she has vampire-like powers and, with the help of her best friend Numbuh One, she must fight her Evil Twin, Haruko.
- Bludgeoning Angel Dokuro-chan: Konata Izumi is an angel sent from Heaven to kill Sasori. Instead, she does something worse — she lives with him.
- Blue Exorcist: After his adoptive father Don Patch is killed, Eren Yeager learns that he's the son of Satan. To train to kick his old man's ass, Eren enrolls at the True Cross Academy - headmastered by Donatello - and gets help from his brother Lelouch. But there are plenty of people who want to harm him, like Franky and Mikado Ryugamine.
- Blue Seed: Mimiru has a bunch of mysterious powers and often slays demons with the help of Yuji Naruo, her Love Interest. In turn, he has a rivalry with Ryoji Kaji.
- Bobobo Bobobobo: Seijuro Hiko joins with Kazu, C.C., Lordgenome, and Saix to prevent Mayuri Kurotsuchi from turning the whole world bald.
- Bubblegum Crisis: Tokyo 2040: Sister Kate Valentine leads a team consisting of Izumi Curtis, Chloe, and Naga the Serpent against robots that go rogue made by a company ran by Gendo Ikari and Aion. As a kid, Sister Kate was Lucy and her father, Van Hohenheim used her in part of his experiments that resulted in said robots. Shinji Ikari is Sister Kate's brother, though he's really a robot himself and a result of the experiments. Chloe is a operator for a specialized police force, whose members include Sousuke Sagara and Il Palazzo.
- Busou Renkin: After being killed by a homunculus, Toshiro Hitsugaya is revived by a strange heart implant that doubles as his signature weapon. His partner-in-action, Temari, fights against the homunculi with a series of blades hidden beneath her school uniform.
- CardCaptors: When her father Miroku brings home a book from the university he teaches at, Ali O'Keefe accidentally releases the seal on the book's cover and sends the magic cards inside scattering to the winds. Ed, the guardian beast of the cards, tasks her with their recovery, bestowing unto her a magic staff and the ability to manipulate the cards' power. Now, alongside her best friend Kitty 'Shadowcat' Pryde, she tracks down the cards, often butting heads with her rival Shane Yamada-Jones and his childhood friend (/cousin) Princess Celestia, all while trying to keep this new life of hers a secret from her family (consisting of her father, and her brother Eddy) and her crush Edd. In time, she even meets the magician who created the cards, Cell.
- Casshern Sins: America is a robot who wanders around attempting to atone for the fact that he killed Francesca Lucchini. Tony Tony Chopper wants him dead but later falls in love with him. His main rival is Jimmy Kudo.
- Castle in the Sky: Rogue and Rex Tamlin try to prevent Dr. Robotnik and Fire Lord Ozai from getting to a floating city.
- The Cat Returns: Mia Thermopolis (her best friend is Veronica Mars) meets with The Dread Pirate Wesley and his friends Frank Barone and Rubin Tishkoff after she accidentally catches the eye of Dr. Frank N. Furter, who wants her for his daughter-in-law.
- Chrono Crusade: Shiraume Noyamano and Negi Springfield fight demons. Negi is a Hunter of His Own Kind. Later, they're joined by healer Misaki Suzuhara and German!Maki.
- CLANNAD: d'Eon de Beaumont has a chance encounter with Kaname Chidori, who is interested in reviving her school's drama club. d'Eon's buddy Negi Springfield gets beaten up a lot.
- Code Geass: The Black Ranger tries to end the occupation of Japan and build a better world for the sake of Mihoshi after gaining powers from Sakura. This is complicated by the appearance of his old friend Ben Tennyson on the other side.
- In the second season, The Black Ranger is leading his resistance out his high school with the help of Hanataro Yamada and Mai Valentine. Ben works together with his own Quirky Miniboss Squad, which includes Eureka and Sora. The Black Ranger also must take down his Magnificent Bastard brother, Madarao.
- Cowboy Bebop: Starscream, Barrett Wallace, Haruhi Suzumiya, and Gaz are four people who try to make a living as bounty hunters while also looking for Starscream's girlfriend Nina Williams and avoiding his greatest enemy: Ben Bertolucci.
- Cyborg 009 (2001 version): Tetsuo Shima leads a Multinational Team of cyborgs to fight against the evil Myotismon. Among his team members are Jin, a hot-blooded punk from New York; Kaoru Kamiya, a French ballerina; Dondochakka, a former legend of the British stage; and Flint, a young baby with incredible psychic powers.
- Deadman Wonderland: Chrono is wrongfully accused of killing his classmates, so he's sent to a hybrid theme park/prison run by Casshern, where Riza Hawkeye works as a guard. He later befriends Renge, along with Alphonse Elric and the second Kenpachi Zaraki. He joins up with a rebellion planned by Sebastian and Cana Albertona.
- Death Note: Quatre Reberba Winner finds a mystical artifact dropped by Tiger of the Wind that causes people to die if their name is written in it. Gambit, the world's greatest detective, tries to stop him. Eventually, Shampoo gets Quatre to reveal his true identity.
- Detective Conan: Jin, the world's greatest detective, is a victim of a poisoning that turns him into Amy. To maintain a secret identity, he moves in with Monkey D. Luffy, his love interest; and Basque Gran, a slacker detective.
- The Devil Is a Part-Timer!: Armin Arlert, the Devil, falls through a portal into Japan, accompanied by his faithful aide, Ukyo. However, his sworn enemy Perona tracks him down. He ends up doing battle with uber-slacker Yoh and pervert Harvar. Also, Happy has a really big crush on him.
- Digimon Adventure: Shobu Kirifuda, Kevin Levin, Suzy, Prince Chagum, Taokaka, Kankuro, and Haruhi Suzumiya all land in a digital world, each gaining their own companion. They face off against the likes of Seijuro Hiko and Thymilph. Juniper Lee later joins them.
- Digimon Adventure 02: Juniper Lee is back, this time with her old friend Haruhi, who has matured into Hamrio Musica. Together with Rock Lee, Sara Goodman, and Hiyori, later joined by Uryu Ishida, they fight to yet again save the digital world. A major antagonist is Spike Spiegel, and the final bad guy ultimately ends up being an old friend of Hiyori's father, Lordgenome.
- Digimon Tamers: Rivalz, Upchuck, and Ed join with many others, including Rosa Farrell, Young Jiraiya, Jamie, and Neji Hyuga to ultimately save Nia from her fate.
- Alternately, Zetsu was just an Ordinary Elementary School Student until one day he found this strange little device called a D-Arc. That night he dreams of a girl he's never met, Luna Platz, directing Ms. Winston in battle. The next morning, he finds himself following the suddenly active D-Arc's directions through the underbelly of the city of Shinjuku until he came upon a strange, otherworldly creature called a Leeron. Thrust into a world he'd only dreamed of, Zetsu soon meets and befriends Yasoo and his partner Po Kong. Together with Luna and her Winston, the three pairs must protect the all-too-easy-to-misplace Son Goku, the Pesci-impersonating troublemaker Keitaro, and keep on their toes to thwart the dangerous Wolverine.
- Digimon Frontier: Mizuki, Toshiro Hitsugaya, Roger Smith, Yoko, and Jim Hawkings are thrust into the digital world, able to transform into various forms. Hitsugaya's brother turns out to be Alucard.
- Dokkoida?!: Fujiwara no Sai is a college student looking for a job. A young green-haired Hyper Blossom provides him with a Utility Belt that transforms him into a diaper-clad superhero. Unbeknownst to them, the supervillains they're fighting against (as well as Sai and Blossom's rival) are all their neighbors.
- Dragon Ball Kai: Five years after the defeat of Roronoa Zoro, Gonard is reunited with old friends Nyamo, Maes Hughes and Buggy the Clown. However, Gonard's son Monkey D. Luffy is kidnapped by his older brother, Yusuke Urameshi. This eventually escalates into a battle for the galaxy against Chouji Suitengu. (Formerly Genkai.)
- Duel Masters: Tai Kamiya plays an absolutely epic card game. Later on he starts to sound a lot like Lloyd Asplund.
- Durarara!!: Charmcaster is a Headless Horseman on a motorcycle. Satoshi Hojo is a newcomer to Ikebukuro, where Charmcaster fights crime. Luckily his friend Zidane Tribal is there to show him the ropes. Itachi has a short temper, especially regarding Lelouch.
- ef ~ a tale of memories: Nagisa Furukawa steals Youhei Sunohara's bike in order to catch a thief who snatched her purse, and she and Youhei later grow fond of each other. Finland meets Misuzu Kamio at an abandoned train station and soon finds out about her sad secret. Meanwhile, Sousuke Sagara is attracted to Youhei's childhood friend, Ayu Tsukimiya.
- The Enchanted Journey: Eustace, a young chipmunk living in the city with his sister Trixie, is enticed by the words of Citizen Kane, the carrier pigeon, to leave home and find the Great Forest, the true home of chipmunks. Setting off alone, he encounters various friends (such as Mr. Magoo the sewer rat) and enemies as he tries to leave the big city and reach his legendary homeland.
- Eureka Seven: Izaya Orihara is a young boy who wants to board like his hero Roy Harper, but he's stuck living in a backwoods town with his grandfather Sarutobi. Then one day, a ship piloted by Mai Lee crashlands in his backyard and he falls in love with her. But the crew, which includes Mai Valentine, Gino Weinberg, and Karin Kurosaki wants to make his life a living hell.
- Excel Saga: Yuri and Tsubaki (and Yuri's dog Rosette Christopher) are two agents of Ken Masters, who intends to take over a city.
- Fairy Tail: Tamaki Kawazoe is a practitioner of Summon Magic who wants to join the eponymous magic guild. She runs into the famed fire-wielding Dragon Slayer Allen Walker and his flying blue cat, Kana Jinnouchi, who happens to be part of said guild. Upon joining, she often finds herself teaming up with him on missions, as well as with the ice manipulating Yutaka 'Panties' Itazu and the always-armoured Lady of War Monkey D. Luffy. The guild itself is headed by the diminutive Bookman, and people such as the sweet barmaid Index, the Rated M for Manly Vegeta, and Hard-Drinking Party Girl Panty are also members. Sloth is Bookman's lightning-manipulating grandson, and is often backed up by his subordinates Switzerland, Yuji Sakamoto and Haruhi Fujioka. Later, water-woman Holo and metal-eating Dragon Slayer Master Chief join the guild.
- The Familiar of Zero: Noel Vermilion is a magician-in-training who is prone to explosive failures. Her only (accidental) success to date is summoning an Earth boy named Bardiche, whom she likes to whip to ensure his obedience.
- Fate/stay night: Viral, who's best friends with Gin Ichimaru, Dr. Neo Cortex, and Skuld, accidentally summons Nanako Kuroi (after being attacked by Lupin III), and then allies with Fuuka and Dist to participate in a Battle Royale for the Holy Grail, facing off against Izanami, Makihisa Tohno, Mikuru, Frederic Chopin, Jin, Temari and finally Diethard Reid and a Prinny.
- Final Fantasy VII: Advent Children: Jason Morgan is consumed by grief over the death of his friends, Angela Hayes and Slips Python. He gets by with a little help from his friends, who include Josie, Spike Spiegel, Hidan, Ogremon, Kenzou Tenma, The Gentleman Ghost, and Kim Possible. Later, Jason fights Superman — who sprouted from Toshiro Hitsugaya — and wins.
- FLCL: Laharl lives a relatively normal life with his friends Mikuru and Gaz. But then Celty shows up and hits Laharl in the head with a guitar, causing a robot to grow from his forehead. And it just gets weirder from there.
- Flint the Time Detective: Ivan Whisky, a cave boy, is revived in the present day and goes along with Rock Lee and Yolei to various time periods to stop the evil Tokiko Yukimura from messing with history. Kenshin is the mission control.
- Fullmetal Alchemist: Ikkaku Madarame and his younger brother Shura attempt to get their bodies back by using a mysterious stone. For most of the series, Cell is trying to kill them. Also, they eventually run into their father Rattrap.
- Fullmetal Alchemist: Brotherhood: After an attempt to revive their dead mother goes horribly wrong, brothers Mao and Chrona join the military with the help of Ace in order find a mysterious stone to restore their bodies. And later, Death The Kidd joins their team...at least until a different Mao sticks Schneizel into his body.
- Full Metal Panic!:
- Sergeant Greed has to protect annoyed schoolgirl Nami with the help of fellow soldiers Broly and Misato. Their submarine captain is A Magic Fish and their recurring enemy is The President of Everything.
- Full Metal Panic? Fumoffu: Sergeant Greed causes much insanity in High School, to the chagrin of Nami. Greed occasionally wears small mecha teddy bear Kaorin. Their schoolmates are Yuka, Sakura,Chuu, and Leo. The student council president is Kei Kurano.
- Full Metal Panic! The Second Raid: Greed is removed from his duty of gaurding Nami while new enemies appear, crazy Sir Crocodile, Creepy Twins Izumi and Osaka, and The Magic Fish's brother, Akito. Selim Bradley/Pride is a prostitute that looks just like Nami.
- G Gundam: Cactus travels around the world with Leilan Katashiro to look for his brother Morio. Giant robots are involved.
- GaoGaiGar: Amelia Wil Tesla Di Seiryunn helps Yami and Dean Venture protect the world from biomechanical aliens.
- Ghost in the Shell: Julia is the top operative in a futuristic police group. She takes orders from Danzo and is assisted by Inspector Runge, Jeremiah Gottwald, and Kefka.
- Girls und Panzer: In an interschool competition in which teams of girls operate tanks, one team consisting of Suzu Mukai, Kasumi Tomine, Chiaki Kurihara, Ritsuko Mukae and Makoto Yokomizo competes with their school's existence at stake.
- Girls Bravo: Superman is a gynophobic wimp that is allergic to women and is constantly picked on and abused by Suiseiseki. One day he is thrown into the bathtub and is warped to a strange Lady Land ware he meets Miranda who is a sweet and kind girl that douses not set off this allergy and lives with her sister Shion. They return to earth and develop a rivalry with Lovable Sex Maniac Chivalrous Pervert Dr. Clive (who is assisted by his Ninja Maid Wendy Earhart) and his Dark Magical Girl Yandere sister Hsien-Ko (she is assisted by The Stoic Roxis and Psycho Lesbian Ryofu). They are later followed back by timid Anglophobic Penny and Bratty Half-Pint Haruko (who brings along Scar a Ridiculously Cute Critter). Their teacher Satsuki turns out to be not only another Psycho Lesbian but also The Dragon of the Gendercideal Big Bad Pan.
- Godannar: Gai Daigoji and Menchi get married and use mecha to fight monsters. They luve together with his brother Touga. However, things get complpicated when his old girlfriend, Hyatt appantly comes back from the dead.
- Great Teacher Onizuka: Perverted teacher Wolverine gets assigned to a school of troublemakers with fellow sane teacher Umi Ryuuzaki, while handling nutcase students like computer geek genius Jade Curtiss, mother-complex student Bang Shishigami and Magnificent Bitch Crimson Viper.
- Grenadier: Busty gunslinger Haruhi Suzumiya travels in order to learn the ultimate battle strategy. She is joined by samurai Viral and balloon maker Milly Ashford.
- Gundam SEED: Ed and Double-D each get a giant robot and find themselves on opposing sides of a space war.
- Gundam Unicorn: Hitsugaya finds himself falling into the cockpit of a mysterious robot after a chance encounter with Mikuru. Misty has a crush on him.
- Gundam Wing: The fate of the world falls on the shoulders of five robot pilots: stoic Vert Wheeler, glory-seeker Hohenheim, amnesiac Miroku, dedicated pacifist Light Yagami, and Arrogant Kung-Fu Guy Kuno The main antagnoists are Megatron and Sherman Cortez .
- .hack//SIGN: Jim Hawking is a young boy trapped in a virtual world. He befriends Leon Kennedy and Rei Ayanami and tries to find out why he's in this predicament. He eventually falls for Mei-Ling, which doesn't sit well with her bodyguard, Cao Cao. Elsewhere, Sanosuke Sagara often fights with Kakashi.
- .hack//Legend of the Twilight: Kirito and Misato are two siblings who earn rare characters for an online game, and often adventure with Mipsy and Lulu. Other players include Justy Tylor, Leeron, and Uryu.
- Haibane Renmei: Solty is an angel-like being reborn within a walled city trying to make sense of how she got there or where she came from. Seong Mi-Na, the eldest of these angels, becomes her caretaker.
- Hellsing: Iron Man is a vampire under the control of Roeas. Yoshino Shinzaike is a policewoman who is turned into a vampire. They fight people such as Father Adam Cooke and brothers Green Lantern and Germany. Adam works for Vatican special operations group Section XIII Iscariot, lead by Ryotaro Dojima. Cooke fights alongside the androgynous priest Kallen Stadtfeld and the berserker nun Morrigan. Later on Hellsing fights against the Nazi group Millennium, lead by the mad German Gideon.
- High School Of The Dead: G-1, Chiyo Mihama, Riru Roukakuji, Shiori Misaka, Issa Mihotoke, and Bulma fight zombies. Black Star joins the group later on.
- Hikaru no Go: Double-D is an apathetic boy who is possessed by the spirit of Light Yagami, a Heian-era Go player.
- Howls Moving Castle: Batman is a wizard and Mike Wazowski is his "assistant".
- IGPX Immortal Grand Prix: Sora, Vasquez, Starfire, Charmcaster, Kisame, and Jessica are part of a racing team coached by General Shepard. Other racers include Alucard, Eureka, Kefka, Kallen, C.C., Crimson Viper, Luke Skywalker, Kadaj, Orochimaru, Doctor Doom, Gin, Rangiku, and Rachel Alucard. Spongebob Squarepants is an announcer who provides commentary for the races.
- InuYasha: Ranma Saotome, a half-demon living in Feudal Japan, falls in love with Amanda Sefton, a high school student who finds herself transported back into the past. Along the way, they befriend perverted monk Teru Mikami, mighty demon hunter Barbie (who falls in love with Mikami), and the fox demon Ning. They also frequently encounter Ranma's brother Optimus Prime and the prideful wolf demon Hohenheim. They're doing all of this to stop the demented Matrix.
- Jojos Bizarre Adventure Stardust Crusaders (2014): Chrom, who belives himself to be possesed by an evil spirit, is greeted by his grandfather, Dong Zhuo, and Gundam Tanaka an Egyptian fortune teller who tells Chrom that the spirit is the cause of Ima Gamagoori's head attached to his ancestor and gaining a Stand. Later, Chrom's mother Kokonoe falls sick because of her stand. They are also joined later by Ryu to save Kokonoe.
- K-On!: Akira Kogami, Yubel, Nanoha Takamachi, Shamal and Madoka Kaname join a light music club. Mileena is their teacher.
- Kazemakase Tsukikage Ran: Izzy is a Sake loving female ronin who is joined in her travels by martial artist Rukia Kuchiki.
- Kaze no Stigma: Four years after being disowned by his father Director Reiji Takayama and cast out of his fire magic-wielding family, Hank Hamada has returned from abroad (as a notably powerful practitioner of wind magic, no less), taking on investigative cases of magical abnormalities as a mercenary. The only one of Hank's former family who's especially pleased to see him again is his little brother Chaos. Hank's second cousin Asuna, who is next in line as Hank's former clan's head, frequently finds herself teamed up with him on his cases (much to her chagrin). Asuna's father Makarov (the current head of their clan) appears to find nothing wrong with trying to hook her up with Hank, while Asuna's friends Eruka Frog and Kazumi Yoshida are all for the idea, too. Hank is usually assigned to cases by Alita Forland (a detective within the local police department specialising in paranormal issues). Asuna gains a rival in Satellizer el Bridget, a representative from an American family who finds herself rather taken with Hank as well.
- Kekkaishi: Edward Elric and Tohru Honda must defend their school from demons along with his ghost dog, Pain. They're later joined by Kira Izuru. Edward and Tohru eventually draw the attention of a squad of bad guys consisting of Sonic the Hedgehog, The Major, Kenshin, Dean Venture, and Johan Liebert.
- Kenichi: The Mightiest Disciple: In order to become stronger, Ox Ford trains with Zazie Rainyday, Whitebeard, Gustav St. Germain, Piccolo, Maes Hughes, Francesca Lucchini, and Nagato.
- Kikis Delivery Service: Mary Jane and her cat Troy McClure move to a seaside town to practice magic.
- Kill la Kill: In order to find her father's murderer, Aladdin and her talking uniform Van must face Kumiko Yamaguchi and her Absurdly Powerful Student Council consisting of Franky, Ichiro Hanzano, Moondoggie and Sayaka Miki. Azusa Nakano stands by Aladdin's side.
- Kinos Journey: Kurumi and her talking motorcycle Sora Naegino travel from town to town having adventures and solving problems.
- Kirby: Right Back at Ya!: Nami and Wobbuffet find a alien puffball in a starship, much to the dismay of JACK ATLAS and Zangulus. To this end, JACK ATLAS asks Knuckles to send him monsters to defeat Kirby. However, Kirby is occasionally helped by a masked Seto Kaiba.
- KO Beast: Yajiro Kojima, Lloyd Asplund and Renko Kamishakunji are three humanoid beasts who seek a mysterious "Treasure" while being pursued by Takefumi Tonami, Jessie and Lina Inverse.
- Kurokami The Animation: Usopp finds and takes pity on a super powerful young demon named Shin Nohara. Together with Shin and his dog Dean Venture, they have to stop the bad guys.
- Little Busters!: The original titular group consists of Kei Kishimoto, Ryou Fujibayashi, Nagisa Hazuki, and Takashi Komuro. Their leader is Ryou's brother Otonashi. Later on, the group adds several girls such as Happy, Miho Nishizumi, Yuuko Amamiya, Chiaki Kurihara, and Kaori.
- A Little Snow Fairy Sugar: Orderly 11-year-old Tsukasa Hiiragi has her plans turned upside-down by a little fairy named Tamachan, who has the power to make snow. They are soon joined by wind fairy apprentice Rosemary and sun fairy apprentice Nawaki, and all of them have taken up residence in her home. Part of the problem is that she's the only human around who can see and hear them. The three need to find a "twinkle" in order to become full-fledged season fairies of their respective types, but they cannot find out what it is, and indeed, have different ideas of what it's like... not to mention that Elder General Lee Fishcake isn't helping much, especially given his fixation on the romantic pursuit of full-fledged rain fairy Cybela, who in turn, seems to have an interest in cloud fairy Mao, who just wants to make the perfect cloud. Mixed up in all this craziness are Marguerite's friends Ayame and Haruka Urashima, inventor Iks, and Rich Bitch and self-proclaimed rival Frillish.
- Lucky Star: Faye Valentine, Pacifica Casull, Aoi Sakuraba and Kallen Kouzuki indulge in nerdy pursuits. Later on, they befriend Nia Teppelin, Yuki Nagato, Mimi Tachikawa and the Pink Space Ranger. Mikuru Asahina and Taniguchi star in a low-budget TV show that airs between episodes.
- Lupin III: Bang Shishigami, Bobobo, Kenshiro, and Yoko are a group of thieves.
- Mai-HiME: Nobue Ito, Kurapika and Miu Matsuoka are among a dozen girls given the ability to summon powerful magical creatures in a battle against shadowy demons threatening them and the lives of their loved ones.
- Mai-Otome: Roll enrolls in a school for Magical Girl Warriors, but her powers can only activate with the help of fake Princess Ana Coppola.
- Macross: Young civilian pilot Kurz Weber comes to Macross Island upon the requests of his mentor Gai Daigogi to see the launch of the SDF-1 Macross,Captain by Gendo Ikari, however Weber is forces into combat when alien, lead by Dracule Mihawk, attack Macross Island. Weber, however he also has to deal with a love triangle between pop singer Asaka and bridge officer May Chang.
- Magic Knight Rayearth: Dita, Konata Izumi and Miaka Yuki are a trio of high school girls summoned to a fantasy world by Neji Hyuga to save Princess Tatsuki from the evil sorcerers Sanosuke Sagara and Lady Vashj.
- Mahoromatic: Miaka Yuuki is a battle android nearing the end of her lifespan, who chooses to live out her remaining days as a Robot Maid serving Keitaro Urashima, the son of her former commanding officer.
- Mahou Sensei Negima!: 10-year-old wizard Chrono becomes a teacher in a Japanese all-girl highschool. Some of his students are Nami, Maka, Winry, Jo, and Rei Ayanami.
- MÄR: Nerdy Shinji Ikari is transported to another world where he fights with a talking mace named Barlowe against a group of chess-themed villains.
- Haruhi Suzumiya: Rozalin forces Itachi to join her new club. Rukia, Eureka, and Lelouch also join.
- Midori Days: Keiichi Morisato is a tough fighter who just wants to have a girlfriend. Without any explanation, his right hand becomes Kiki Benjamin.
- Mnemosyne: Private investigator Eclair and her assistant Aki Hinata happen to be an immortal couple.
- Monster: Coyote Starrk is an insane mass murderer, and Nightcrawler is the man dedicated to bringing him to justice. Seijuro Hiko is the man dedicated with bringing Nightcrawler to justice.
- Mon Colle Knights: Ken Ichijouji and Gimmy run afoul of the evil Hachigen Ushoda.
- Moribito: Guardian of the Spirit: Kushina Uzumaki is a powerful warrior who vows to protect Izzy to atone for her sins.
- My Bride Is a Mermaid: Allen Walker, along with his parents Father Cornello and Trisha Elric, get in big trouble with a mermaid yakuza led by Gendo Ikari and his wife Echidna Parass. Also, the kid gets a mancrush on Piccolo.
- My Neighbor Totoro: Coraline and her real-life little sister have strange and wonderful adventures when they move to the country with their dad, Superman.
- Nana: Two strangers with the same first name and contrasting personalities — perky college student-to-be Sango and cool, aloof rocker Sunset Shimmer — meet on a train and move out to Tokyo to find new purpose in their lives, forming an Odd Friendship in the process.
- Naruto: Piggley Winks, Haseo, and C.C., are three ninja training under Upchuck in order to become master shinobi. At the end of the series, Haseo does a Face–Heel Turn and joins Wolverine in order to kill his brother, Kyon. C.C. decides to train under Meryl Silverburgh in order to get stronger. Piggley leaves the village to train with Kenpachi Zaraki.
- Naruto Shippuden: After training for 3 years, Piggley returns to his village and, with the help of Kai and Excalibur, seraches for his missing friend Haseo, who has formed a team involving a Prinny, Roy Mustang, and Lightning. In addition, Piggley also fights a sinister organization that includes Kyon, Black Jack, Portgas D. Ace, Chris Redfield, Lelouch Lamperouge, The Hulk, Cid Highwind, Kaoru Kamiya, and their leader Van Kleiss, who is actually a puppet controlled by Edward Elric... and he's working for Tychus Findlay.
- Later, Piggley discovers that his parents are Bang Shishigami and Balsa. Afterward, he trains with The Black Baron in order to control his Superpowered Evil Side, Xenmas.
- Naruto: Ninja Clash In The Land of Snow: Piggley, C.C., Haseo, and Upchuck head to the Land of Snow to save Princess Anemone from bad guys.
- Legend of the Stone of Gelel: Piggley, C.C., and Mushra go to a strange land to help Captain America save the day. They're helped massively by Dr. Tenma and his siblings Kyoji Mujo and Jennifer Nocturne.
- The Last: Naruto the movie: Two years after the final battle and bringing Haseo back to the light, Piggley became the greatest hero of this generation. However, this newfound popularity upsets Yui Hirasawa, Piggley's love interest. However, when Yui's sister Sora Takenuchi got kidnapped by Mamoru Chiba, she joins Piggley's squad along side C.C. Kai and their leader to find her. During this adventure, Yui will find out that she has a great potential while Piggley will find out about her feelings for him.
- Nausicaä of the Valley of the Wind: A doomed bank clerk and her uncle Jean-Luc Picard (along with Admiral Adama) defend their peaceable kingdom from Beatrix Kiddo and Jack Skellington with help from Sam Witwicky and his town's mayor, Luke Skywalker.
- NEEDLESS: Honey Haninozuka, sole survivor of La Résistance, joins up with Maki and Mei Ogawa, a superpowered duo. Menchi, Teletha Testarossa and Chiyo Mihama are an Amazon Brigade.
- Neon Genesis Evangelion: Three unstable teens—shy Arakune, brash Altena, and seemingly emotionless Rally Vincent—are forced by ruthless leader Shinigami-sama to battle "Angels" while under the command of Sgt. Maj. Melissa Mao and Big Mama.
- Nerima Daikon Brothers: Negi Springfield,Yukari Tanizaki and Ohjiro Mihara try to get enough money to open a concert hall while being pursued by policewoman Sayoko Yamazaki.
- Nightwalker: Vampire Detective Izumo Kamizuki is joined by agent Victoria, Girl Friday Mimori Kiryu and imp Sumomo.
- Night Raid 1931: Chrono, Daiju Mononobe, Toshio Ozaki and Yuri Nakamura are super-powered spies working from the Imperial Japan in 1930's Shanghai. Dante is Yuri's long lost brother and Chorno's girlfriend is Eucliwood Hellscythe.
- Noir: Mafia Princess turned assassin Canaan and Badass Adorable Hyatt find themselves involved in the schemes of Knight Templar Chestmaster Asuka Langley Soryu. Rosette Christopher is one of Asuka's minions.
- One Piece (Funimation dub): Riza Hawkeye starts her own pirate crew, recruiting swordsman Daisuke Jigen, navigator Yukari, sniper Krillin, chef America, doctor Rei Ayanami, archaeologist Arachne, shipwright Isshin Kurosaki and musician Toriko.
- Ouran High School Host Club: As punishment for breaking an expensive vase, Winry Rockbell is forced to join Kurz Weber's "Pretty Boys" Club to earn her keep. Other members of said club include twincestuous brothers Italy and Negi Springfield, Vice President Scar, boy lolita Medusa and his stoic companion Cell, as well as their manager, PenPen.
- Paranoia Agent: Tsukasa Hiiragi, best known for creating Kaede Fuyou, is bludgeoned by a bat-wielding spoony bard. Kano and Dr. Tenma are sent to investigate the attacks.
- Panty & Stocking with Garterbelt: Angels Liz Thompson and Tsubaki, under the command of Piccolo, battle vengeful spirits (when they're not binging on sex and sweets, respectively).
- Pokémon (4Kids version): April O'Neil is a Pokemon trainer who goes on a journey with Princess Charlotte and Seto Kaiba to become the greatest Pokemon master while stopping the evil plots of Ursula, Meta Knight, and E-123 Omega.
- Pokémon (Diamond and Pearl): April (now Alicia), still aspiring to become a Pokemon master, is joined by Shinobu, and Kaiba (now Tanaka Soichiro) in the Sinnoh region. They make sure to prevent Koyuki Asagiri, Lt. Toudou, and Vector the Crocodile from stealing Pokemon. Eventually, the trio fight an even greater crime syndicate headed by Goku.
- Pokémon (Black and White): Alicia goes to the Unova region. Penchinon becomes her rival, while Belldandy and Sonic the Hedgehog become her traveling partners.
- Pokémon Origins: Kirito and Ja'far start their Pokémon journey when they receive their Pokémon from Prosecutor Edgeworth. On their journey they become stronger by battling Gym Leaders like Itsuki Koizumi as Kirito gets involved in taking down the nefarious Team Rocket run by Yukio Oikawa.
- Ponyo: Aslan, who thinks Humans Are the Real Monsters, (his wife Galadriel, the Anthropomorphic Personification of the ocean has a much more easygoing attitude) is horrified when his goldfish/mermaid daughter Noah Cyrus meets cute with The Jonas' youngest brother. Meanwhile, lil' Jonas' mom Liz Lemon works at an old folks' home where she cares for Rose Nylund and Frau Blucher! (* CRASH!* * NEIGH!* ) and is upset when her husband Jason Bourne can't come home on time when a very Cozy Catastrophe engulfs their seaside home.
- Princess Mononoke: John Connor's girlfriend, her she-wolf mom Dana Scully, and Dr. Manhattan try to protect a forest from Jane and Karl Childers, with help from Nurse Hawthorne.
- Psycho-Pass: Misaki Kirahara joins the police force composed of Axton, United Kingdom, Naru Arata and Chiyo's dad and led by Ichika Orimura.
- Puella Magi Madoka Magica: Squid Girl, daughter of Office Lady Mokona and House Husband Kamina, was contacted by a distant Nanoha Takamachi to never become a Magical Girl... until she met both Ritsu Tainaka and her fellow Magical Girl Casca. Squid Girl almost considers becoming one until Casca got her head chomped off. Later on, Casca's shoes were filled by a cynical Litchi Faye-Ling while Ritsu starts showing off much more sinister agenda while Nanoha hunts her down. Squid Girl's friend Peacock also becomes a Magical Girl that spirals down in despair to become a witch that had to be killed by Litchi's sacrifice. Nanoha failed her job and Squid Girl makes a drastic decision...
- Puella Magi Madoka Magica the Movie: Rebellion: In what seems to be a happier iteration of the world, the five girls plus strangely familiar Team Pet Sachi defend Mitakihara from creatures known as Nightmares. It comes to a head when Squid Girl and Peacock's friend Mugi continues to be rebuffed by her boyfriend, LittleKuriboh's wife, and spawns a Nightmare herself. But wait — Nanoha feels like there's something wrong, and is determined to figure out what's truly going on.
- Queen's Blade: Kanuka Clancy, Jessie, Yuu Imagawa, and Excel are part of a group of well-endowed beauties who bare all in a worldwide fighting tournament.
- Ranma One Half: InuYasha is an expert martial artist who turns into Jean Grey when splashed with water. Sulia Gaudeamus is a tsundere. They are thrown into an arranged marriage by their fathers (Soundwave and Captain America, respectively). They aren't too keen about this, and neither are their various suitors (which include Near, Boss, Princess, and Mr. Greenrind).
- Rave Master: Cecil Harvey is the titular Rave Master, a hero who works alongside Yoko Littner to protect the world from imminent destruction. They're later joined by the powerful silver-claimer Squall Leonhart, martial artist Guame, and the ever-popular Sponge Bob Square Pants.
- Real Bout High School: Samurai girl Faye Valentine and Hot-Blooded punk Eikichi Onizuka are the top fighters in their school.
- Revolutionary Girl Utena: Misty, a tomboyish girl whose goal is to be a prince, must defend Rose Bride Alka which means dueling the Student Council consisting of Hideki Motosuwa, Komaki Asagiri and Gary Oak.
- Rozen Maiden: Kite is a shut-in whose main companion is a living doll named Rena Ryugu. Rena and several other dolls - Kallen Kouzuki, Nunnally Lamperouge, Milly Ashford, Mio Akiyama and Skuld - make Kite's life an even bigger living hell in their battle for the right to become the "perfect girl".
- Rurouni Kenshin: Legato Bluesummers, a samurai who has sworn never to kill again, ends up crashing at the residence of Francoise, a young kendo practitioner. He also befriends martial artist Kenshiro, Kid Samurai Haruhi Suzumiya, and master medic Katsuyu. Later, he's conscripted by Don Patch to go fight Rockwell, who's amassed an army consisting of, among others, Circe, Mayuri Kurotsuchi, Charles zi Britannia, and Angemon.
- S Cryed: Leeron and Kid Flash are two transformed humans who fight to protect the world. Kari Kamiya is really into Kid Flash.
- Saber Marionette J: On a planet populated entirely by men, Rokuro Okajima, a poor but hard working young man, finds himself with three female androids: Genki Girl Madison, Yamato Nadeshiko Lum Cheng and Shenhua.
- Sakura Diaries: High School Graduate Shinichi Asakura seeks to enter a prestigious university, but ends up in a triangle between classy beauty Hyatt and his cute cousin Ringo Seto.
- Sailor Moon: We get a double dose of Courtney in both the DiC Entertainment and Cloverway versions of the show.
- DiC: Dryad (later Jellico), along with Hello Kitty, Gwen (temporarily Courtney), Angel and Yin, are sailor scouts. Dryad's boyfriend is Batman.
- Cloverway: It's Yin's turn to be Courtney. Jellico (now The Wicked Witch) meets three new sailor scouts: Molly Meade, Sailor Neptune, and Sheila (now a nurse).
- Viz Media: Hinata Hyuuga, the Scarlet Witch, Alisa Boskonovitch, Megumi Wakamiya, and Lucy Heartfilia have to fight the forces of evil, starting with Queen Labrys (whom herself works for Motoko Kusanagi) and her forces, including Death the Kid, Air Raid, Hifumi Yamada, and Luke Valentine. SwaySway is Hinata's boyfriend, and Rukia Kuchiki and Adam Park are a pair of talking cats who, respectively, belong to Hinata and Lucy. Hinata goes to school with Batgirl and Venom, and their teacher is Meia Gisborn. Waver Velvet works at an arcade Hinata frequents, and Hinata's family includes Coyote Starrk, Eva Heinnmann, and Mikey Kudo. Scorpina and Squatt are respectively Hinata's mother in a past life and Alisa's grandfather.
- Sailor Moon R: Hinata, Scarlet Witch, Alisa, Megumi, and Lucy are enjoying peaceful lives, with no memory of what happened, but with Rukia and Adam have to jog their memory after the brother-sister duo of Renzou Shima and Meryl Strife come calling. SwaySway also no memory of what happened, either, but someone with a similar M.O. is around. Later, Hinata and SwaySway have to deal with their daughter from the future, Guni, who is being pursued by Darkonda, Tygra, Cerise Hood, and Cytomander the Swift. Cytomander has Shadowcat, Pepper Potts, Di Gi Charat, and Leafa working for him. April O'Neil is helping Guni.
- S: Ryuko Matoi, Kyoko Sakura, and April appear just as Hinata deals with Blast Off and his daughter Azusa Nakano. Tron Bonne, Nazz, Honoka, Cindy Cambell, Mari Myers, and Creepy Twins Gnar and Kaoru Kamiya work for Blast Off.
- Sailor Moon Crystal: As Viz is dubbing it, it retains the same voices as their redub of the original, but as it's Truer to the Text, Renzou and Meryl aren't present and as a result, Hinata, SwaySway, and company go directly from dealing with Labrys and her forces to Darkonda and his. Also as a result of Truer to the Text, Death the Kid, Air Raid, Hifumi, and Luke have a history with SwaySway in their past lives.
- Saint Seiya: Sha Gojyo, Kurama, Il Palazzo, Ichiro and Gauron are young warriors who must protect Kagura who happens to be the incarnation of the goddess Athena.
- Saiyuki: In the world of Shangri-la, the Buddhist order commands Jerkass monk Sanosuke Sagara to travel westward to India and prevent the resurrection of an ancient, powerful demon. Accompanying him are Keet Keigo Asano, Team Mom Shiro Amada, and Chivalrous Pervert Bang Shishigami.
- Samurai Champloo: Tsuruya manages to trick Spike and Saix into becoming her bodyguards in order to find a mysterious samurai.
- Samurai Pizza Cats: Fu-Fu, Mrs. Radcliffe and Darph Bobo are feline superhero samurai who work in a pizza place as they fight ninja crows.
- Samurai 7: In order to protect their village, Makina and Sebastian go search for samurai. They end up hiring Richard Moore, Koenma, Chrono, Mr. 3, Sig Curtis, Ragnarok, and Vegeta.
- Scrapped Princess: Princess Ashe is marked for death on her sixteenth birthday, seemingly hunted by everyone in the world to prevent her from triggering the apocalypse. Her adopted siblings, master swordsman Kyon and master mage Lain Iwakura, have sworn to protect her as if she was one of their own.
- Sgt. Frog: Allen Walker plots to take over the earth (and fails epically), joined by Georgie, Yamcha, Hiei, and Eneru along the way.
- Shakugan no Shana: Radu discovers to his horror that the world isn't what it seemed, and is rescued by Rarity from being eaten, who callously informs him that he is basically a zombie. Rarity is contractually bound to slay Crimson Lords by the Juggernaut, with whom she is able to communicate through the pendant she wears. Feldt Grace is Radu's classmate, and has a crush on him. Orange Blossom is a Hard-Drinking Party Girl who casts spells using nursery rhymes, whenever she isn't telling her book Hot Dog to shut up. Pepper Potts, Rarity's former caretaker, attempts to kill Radu until Rarity interferes.
- Shaman King: Drew is a ghost-obsessed kid who befriends Marcel, a shaman who is engaged to Circe. Together with Marcel and his spirit companion Goku, he goes on adventures with Dean Venture, Gonard, and later Kid Muscle.
- Silent Mobius: Luchs, a sorceress of no small power, joins an all female police force consisting of cyborg Eda, esper Sango and hacker Kyoko Otonashi, all under the command of Morishita's wife to fight a race of extradimensional monsters.
- Slayers: Deedlit and Brock fight demons and hunt for treasure. Delia Ketchum, Touga Kiryuu and Sanji (later replaced by Leonardo) occasionally provide support.
- Sonic X: Cilan is the king of speed, who, with help from Lina Inverse and Yami Yugi, helps fight off such guys as Meat and Keita Ibuki.
- Soul Eater: Evangeline A.K. McDowell and her partner/weapon Malek Werner battle demons and witches like Ms. Yukari, and her Axe Crazy daughter/son Ellis, along with their friends, Keroro, Riful, and Suzuka, by the request of Death himself, Gendo Ikari.
- Space Dandy: Bardroy is a dandy guy... in space! With the help of his Robot Buddy Conan Edogawa and Funny Animal Saburo - and occasionally helped by Monkey D. Luffy - he aims to catalog rare alien species. But there's danger afoot - both Rikichi and Soul Eater - both backed by Father - want him dead. Adam Park is a good friend of Dandy who turns out to be the commander of the forces opposing Father. Dot Pixis narrates.
- Spice and Wolf: France is a traveling merchant who comes across Eve one day. Together, they face the consuming evil of...economics.
- Spirited Away: Lilo saves her parents (including her father, Vic Mackey) with help from Discord, Megera, and Timmy Turner. The villain is Zira. Other denizens of the spirit world include Jumba, Hamm, Squidward and Porky Pig.
- Squid Girl: Azusa emerges from the ocean with the intent of punishing humanity for polluting her home. She attempts to make a small beah hut restaurant, run by sisters Aya and Tsumugi, into her base of operations, but, after breaking a hole in the wall of it, she's forced by the two to work for them as a waitress. Their younger brother Megumi likes to play with Azusa. Gozumaru is one of the beach lifeguards, who has a rather obvious like for Tsumugi. Azusa is frequently forced into fetishistic cosplay outfits by Ui, and, Mio appears to be the only person who views Azusa as the threat to humanity she tries to be.note
- Stepmother's Sin: Yami manipulates his stepmom, Yaku, to have sex with him.
- Steamboy: Rogue is the hero of this Steam Punk fantasy. Rogue's grandfather is Captain Picard.
- SteinsGate: France, who fancies himself as a mad scientist, sends a text who was sent to the past which prevents Lan Fan's death but also leads to a series of event ending in France's childhood friend, Cassie Cage dying. Broken yet determined by Cassie's death, France decides to change her fate even if it will ruin the happiness of his other friends like the part-timer/time traveller Asuna Yuuki and the boy turned into a girl Nagisa Shiota.
- Strawberry Marshmallow: Mai Tokiha unwillingly plays host to the antics of her younger sister Alyssa Searrs, and her friends Mikoto, Mashiro, and a Cute Clumsy Girl in glasses.
- Strike Witches: Setsuna Sakurazaki is recruited by Osaka and Aria to join a group of female pilots who fight aliens with powerful jet engines strapped to their legs...but never wear pants.
- Sword Art Online: Shugo is a skilled beta tester who finds himself trapped in a virtual world of Roronoa Zolo's creation — though he masquerades as Kain Fuery in game. He has to lead an unlikely crew — including Lucy Heartfilia, Isshin Kurosaki, and Shiro Fujimoto — to victory.
- Fairy Dance arc: Lucy's Bastard Boyfriend Death the Kid attempts to force her into marriage, so Shugo has to play again, this time aided by his cousin Saki and her friend, the lady who introduced Pegasus.
- Phantom Bullet arc: Shugo plays an FPS in order to investigate the real-life murders of some of its players. Numbuh 1 is apparently behind the murders. Shugo meets Yoko Littner, and together they team up to hunt down Numbuh 1. Yoko's friend Makoto Tachibana is creepily obsessed with her and is also one of the three people who control Numbuh 1.
- Caliber arc: Shugo gathers Lucy, Shiro, Uni, Nepgear, Saki, and Yoko on a quest to acquire the prized sword, Excalibur.
- Mother's Rosario arc: Lucy befriends Ryuko Matoi and helps her guild defeat a boss before AIDS claims Ryuko's life.
- Tales from Earthsea: The Green Goblin, Det. Benson, Rassilon, Ramone, and Manjula Skinner live uneasily amid magic and morally ambivalent shadows.
- Tengen Toppa Gurren Lagann: Sasuke and his best friend Wario both pilot a giant robot and, with the help of Rukia, battle an army led by Chad, and his minons, Xemnas, Shizune, Kadaj, Psycho Mantis, and Shirou. He also falls in love with Starfire along the way who becomes Belldandy, messenger for the dreaded Anti-Spirals, lead by Angemon.
- Tenjho Tenge: Neji Hyuga and Jelly Jiggler are two new students at Todo Academy. They join the Juken Club, a fighting club consisting of Haruhi Suzumiya, her younger sister Orihime Inoue, and Lelouch Lamperouge, who has a crush on Orihime.
- Tenkai Knights: Izaya Orihara is a new transfer student, who finds himself fighting for the fate of another world against the evil Ebisu. Thankfully, he's backed up by his friends - worrywart Sugou, star athlete Nagito Komaeda, hardcore gamer Szayelapporo Grantz, and otherworldly soldier Karasu. They also have to deal with the mysterious Haru Glory.
- Tiger & Bunny: Renji Abarai, an aging but spirited Man Child superhero, is forced to team up with the "rookie with an attitude," Suzaku Kururugi. They work for HeroTV, a channel founded and run by Malik Caesar. Together, They Fight Crime, competing against a cast of colorful superheroes including Germany, Ashelia B'nargin Dalmasca, and Roy Mustang.
- Trigun: Nero, who was once Zidane, roams the land for his brother Tetsuya (who was once Maruss). He is followed by Kamiya Kaoru, Chun-Li, and Viewtiful Joe.
- Tsubasa Reservoir Chronicle: Hei travels with Zoro, Nagato, and Miu to regain May Chang's memories.
- Ultimate Muscle: Faust VIII is a cowardly wrestler from another planet. He befriends the Texan Yusei Fudo, walrus-man Meowth, and the humanoid gazelle Seto Kaiba. His love interest is Lina Inverse.
- Vampire Princess Miyu: (OAV) Princess Shiina is a vampire girl who, alongside her servant Gibson, must hunt down a race of demons. She crosses paths with Sora Hasegawa.
- Welcome to the N.H.K.: Yuichi Aizawa is a shut-in who believes that he's the victim of a conspiracy. His Otaku neighbour Pope Alessandro XVIII and Kouko Ibuki (a girl claiming to be working for a charity project) try to pull Yuichi out of his rut. In time, Yuichi is drawn into an ultimately botched suicide pact by Kirino Chiba, and, later, into a pyramid scheme by Stocking.
- X1999: Banagher Links returns to Tokyo and must decide the fate of the world either to save it or destroy it. His childhood friends, Yuki Nagato and Alucard, are involved in this situation
- Xxx Holic: Allen Walker stumbles on a mysterious shop owned by Riza Hawkeye, who can grant wishes unless there's a price.
- Yu-Gi-Oh!: Knuckles The Echidna, former pharaoh of Egypt, is reincarnated in the body of Nezumi, who solved his puzzle. Together with Nezumi's friends Michaelangelo, Yusei Fudo, and Max, and Knuckles's rival Brock, they play children's card games. Michaelangelo has a romantic subplot with Rangiku Matsumoto. All of the good guys join forces to ultimately take down JACK ATLAS.
- Yu-Gi-Oh! GX: Zero enrolls into a duelist academy, where he becomes friends with Fred Jones and King Dedede, as well as finding rivals in Casey Jones and Gonard. Eventually, he battles Kuina and discovers she was his best friend in his past life. Finally, he battles against Grovyle.
- Yu-Gi-Oh! 5D's: Big The Cat recruits Tristan Taylor, Tracey Sketchit, Luffy, twins Tory Lund and Zoey Drake, later joined by Johnny Steps, (who later on gets replaced by Gible). The six of which have been marked to fight Duke Devlin, and his minions Codemaster Hotekk, Doctor Shishioh, Ash Ketchum, Kidd Summers and Goku.
- YuYu Hakusho: Delinquents Russell Tringum and Garland are conscripted by Ren Mihashi to kick some demon ass. Dr. Stein and Tien Shinhan later join them. Freeza trains most of them. Halfway through the series, America invites Russell and company to fight his own team, which is led by Cell and includes Yoshimori and Kamina. After that's all said and done, Russell has to fight his predecessor, Donquixote Doflamingo. Finally, Russell learns that his father is Vegeta.
- Zatch Bell!: Bartz Klauser is a stuck-up genius who is hated by everyone in his class except Nel Tu. This changes when he befriends Jimmy Neutron, a young boy who wants to become king of the demons. Later on, Bartz joins Lucrezia Noin and her partner Jon Arbuckle to help save Lucrezia's friend Kari Kamiya from the evil Wuya.
- Zoids: Chaotic Century: Amuro Ray discovers a pair of capsules which contain Master Asia and Allenby. They soon run into Mega Man X and Hinoki Sai who soon join them to stop the evil plans of Bright Noa, master of the Bright Slap. Soon enough Amuro encounters a mysterious rival known only as Goten.