Ace Combat 5: The Unsung War: Gives us a 3 person variant when the enemy forces finally manage to kill off Chopper. The enemy pilots get to savour a few seconds of relieved cheering mainly along the lines of "see, they're not invincible after all!"... At which point you and the rest of the squadron proceed to completely destroy EVERYTHING ELSE IN THE AREA as payback. By the time the mission's over, the few surviving opponents are almost literally running away crying for their mommies.
American Mc Gees Grimm: "Cinderella was not simply an ill-used ninny who married well, forgave her tormentors, and lived happily ever after. She was innocent, she was abused, she was harmed. HER PAIN SHOULD BE PAID FOR!"
Assassins Creed II: Ezio starts out with the family business of killing people in revenge for the death of his father and two brothers. Then it extends to that family's bosses, and their bosses, right up and into the Ancient Conspiracy central to the game, for over thirty years. To reword Seanbaby:
At the time, the country of Italy was using Ezio Auditore to control the aristocrat population and they occasionally dragged him on a chain through the air to hunt Templars in the least humane way possible.
In a bit of a subversion, however, by the last quarter of the game, Ezio is shown to be getting tired of his constant desire for revenge, which dovetails neatly into his plan to set up the Assassins Brotherhood to oppose the Templars systematically rather than in a reactionary way in Brotherhood and Revelations.
In Brotherhood, he finally stops and spares the one who caused it all. Sparing Borgia turns out to be a bad idea after all.
Conner from Assassins Creed III also performs one against Charles Lee for burning his village and killing his mother.
He does this again in Revelations when he finds out about Yusuf's death and Sofia's kidnapping.
Asura's Wrath: Asura out rivals EVERYONE on this entire Trope page when it comes to this. He will stop at NOTHING to get his daughter back. He takes this EVEN FURTHER when a girl that looks like the daughter his is trying to save is killed by the Seven Deities along with her entire village. by destroying the ENTIRE FLEET that Olga sent to destroy said village. If anyone represents the Patron Saint of this trope, it's Asura.
Borderlands2: Mordecai has a big one after Handsome Jack mutates his pet Bloodwing and kills her. Normally, Mordecai uses a sniper rifle with a slag effect, but after the event happens, he screams on the top of his lungs and blasts the Hyperion robots with explosive shots, stronger than the game's standard explosive element and strong enough to take out the robots in a single hit. Later on, Mordecai has you attack Hyperion's wildlife labs in revenge.
All of the experience when playing as Krieg's is this when fighting Hyperion, who brutally experimented on him to give him his superhuman abilities but broke his mind in the process. Getting payback against Hyperion is one of a very small number of things both sides of his mind can agree on.
Bulletstorm: The entire background for Grayson Hunt, the anti-hero protagonist, consists of this somewhat mixed with He Who Fights Monsters. Graysons unit was employed for assassinations of innocent civilians (such as reporters) by the Big Bad of the game, a seemingly insane, utterly ruthless general, apparently for personal gains. However, the nature of the targets was not revealed to the team, who believed they were eliminating terrorists, pirates, slavers and so on. After finding out that they have been used as killers, Grayson vows to kill said general, defects (together with his men) from the army...and becomes a pirate himself, descending into almost psychotic aggression, fueled by alcoholism. Just how far he is willing to go is exemplified by the beginning of the game: he crashes his ship into a military cruiser, believing the antagonist to be on board (plausible, as it's the flagship of the fleet) in a suicide attack - sacrificing his own crew (save for one person) and taking into account the deaths of over a thousand (the number is explicitly stated) enemy crewmen whose only fault is to be on board of the ship his enemy is on.
Dark Messiah of Might and Magic: If the player is trying to achieve the good ending, Leanna appears to be killed by the Necromancer Arantir, when the player arrives at his lair later the guards almost seem afraid of the players wrath as he becomes an unstoppable juggernaught of revenge, the player can then rescue her from the lair to get the good ending.
Darksiders: The entire premise of this game is that the Horseman of War is on a quest to kill the ones responsible for his fall from grace. Samael even honors his deal with War when he could easily betray him because he actually respects a good ol' Roaring Rampage of Revenge. When he discovers that the Charred Council made him their Unwitting Pawn and faked his fall from grace in a breach of the pact he and the rest of the Horsemen obey, he decides to go after them with the help of his fellow Horsemen.
Dissidia: Final Fantasy: After beating the main story, you can select SNK boss Chaos in quick battles, set him to level one, and then select a level 100 character. Proceed to curbstomps for every last retry you were forced to endure in story mode.
Dynasty Warriors: In every game, Liu Bei and Zhang Fei get sent into this when they find out that Wu has assassinated Guan Yu and Guan Ping. Result a Genocide leaving no one in Wu alive.
The Elder Scrolls V: Skyrim: You can do this if you join the Stormcloak rebellion. The perspective of a player character in that scenario is that the Empire was about to execute him/her at the beginning of the game for being a Stormcloak even though the player had no prior involvement with them.
You can also go on a rampage against the Dark Brotherhood after killing Astrid, though you will have to visit Aventus Aretino and kill Grelod the Kind for him. Given the number of assassins that she likes to send after you during the course of your quest, you'll most likely want to do something about them.
If you have the "Hearthfire" expansion, you can rampage against the bandits who have taken your wife/husband hostage from one of your plots of land, starting with the messenger.
Fallout: New Vegas: Craig Boone devotes his life to destroying the Legion, who bought his wife as a slave and forced him to perform a Mercy Kill on her, and will sign up to aid you if you promise him the opportunity to fight against them.
Courier: Any thought's on Caesar's Legion?
Boone: Lots of thoughts. All about the best ways to kill them.
Also a way to play the Courier if you decide to head straight for Benny without stopping for anything along the way. However, you cannot kill Yes Man, who masterminded your murder (though he only knows you're the Courier he helped kill if you tell him, at which point he apologizes) due to the fact that he is one of the few immortal NPCs of the game, albeit with justification. He apologizes for this as well, telling you that your revenge must feel empty because of this.
Final Fantasy IV: Seeking revenge for the death of his daughter, Tellah tries to kill Golbez with Meteo even though casting this powerful spell means Tellah's own death.
This isn't this trope, but simple revenge. Tellah doesn't gun for all of Golbez's minions and try to blast every last one of the Red Wings out of existence in a gory show. He wants Golbez's head on a pike, commits a Heroic Sacrifice to try to destroy Golbez, and fails hardcore since Golbez survives with his Plot Armor. Tellah's Plotline Death is setting up a double subversion of The Only One Allowed to Defeat You, since he fails, Cecil is set up as the one who should defeat Golbez, and then in The Reveal Golbez survives because he was being controlled by the Eldritch Abomination.
Final Fantasy VI: After his wife, his son, and his king (along with almost everyone else in Doma castle) are killed by Kefka's poison, Cyan rampages through the Imperial camp. Partly subverted in that Sabin and Shadow come to Cyan's aid and the three end up escaping from the camp.
Final Fantasy VII: Sephiroth learns the "truth" that he's a descendent of the ancients, then goes berserk & burns down the town of Nibelheim. He later learns the truth behind the "truth," but continues with his plan to become a God, transferring "descendent of the Ancients" to "descendent of Jenova." A good deal of his actions—which also become his downfall—are also that he wants to get revenge on Cloud for defeating him in a fairly humiliating fashion.
It is to be noted while he acts that way towards the immediate person who dealt the killing blow, his revenge on the corrupt society behind the killing was much more... planned.
Argath has a less subtle version which crosses the Moral Event Horizon. After being resurrected by the Lucavi, he loudly declares to Ramza that he's going to kill all of the lower class, presumably in part to get back at Delita for killing him.
First Encounter Assault Recon (F.E.A.R.): This is just one looooooooooooooooooooooooong example of being on the other side of this trope. Alma is a very unhappy girl.
Ghost Trick: The Big Bad spends years carrying out a meticulously crafted plan to punish everyone involved with his death, including the then-young girl he took hostage.
The Godfather: This game is essentially one of these for player character Aldo Trapani. Don Emilio Barzini had your father killed. You get recruited as a Corleone hatchetman. It's convenient that the Corleone goals of taking over NYC and crushing the other four families align with your own.
Revenge is the central theme in God of War. Pretty much boils down to this: If they've crossed Kratos, they're going to die. Along with anyone and anything that stands in his way. Including Fate itself.
Also a deconstruction, as Kratos' unrelenting desire for revenge ultimately has dire consequences, showing how one man's desire for revenge can destroy everything that he once held dear ( first, his family is destroyed because he wanted revenge against the man who defeated him in battle, and then, ultimately, the whole world suffers for his devastating rampage).
Grand Theft Auto: Chinatown Wars: An early mission involves driving through the turf of rival dealers while your employer opens up on everybody with a machine gun in retaliation for stolen business. Oh, and a previous mission involves tracking down someone who cheated him and cutting his heart out.
Half-Life 2: Gordon Freeman enters the enemy base, alone, at the end of the game. All his weapons are taken from him, except for the Gravity Gun, which becomes ultra-powered and capable of even grabbing enemy soldiers. All his friends have been captured. The entire end-game segment lets the player go berserk on the enemy with the Gravity Gun, torturing and maiming them in every way imaginable, while Dr. Breen, his old supervisor, calls him worthless.
Its very likely the entirety of the next episode will be like this for the PLAYERS considering Eli's death at the end of Episode 2.
The Halo series: Hunters form bonded pairs with one another and always fight together. If one goes down, the other will furiously redouble its efforts to reduce you to a bloody pulp.
The Precursors, after denying the Forerunners the Mantle in favor of humanity and planning to cull them, are hunted to near extinction by a massive Forerunner military force. A few escape though, and were understandably not happy. Their plan? Make sure that everything they've ever created suffers for all eternity. The form they took to accomplish this? The Flood.
Heavenly Sword: This game has Nariko going on one of these when King Bohan kidnaps her father. She literally tears through his entire army to get at him.
House of the Dead: Overkill: The exact words of the trope name are used by the narrator when describing Varla's motivation. (Her brother turned himself into a monster while trying to kill Papa Caesar, so she wants Papa Caesar dead. The heroes are the ones who actually killed her brother, but it was a I Cannot Self-Terminate, so they don't get the blame.)
And while we're on the topic of Kingdom Hearts, Roxas in 358/2 Days. He was forced to kill and absorb one of his best friends, so he ends up going on a one-man invasion of the entire World That Never Was to set Kingdom Hearts free and put Organization XIII in their place, easily taking out Neo Shadows in a single hit. And throughout all of this his memories of Xion are fading, to the point that when he begins his battle with Riku he only remembers his best friend as "her". Unfortunately for Roxas, Riku puts a stop to his rampage before he can even get to the Castle That Never Was. In the end, it was probably for the best, since if Roxas got himself killed fighting Xemnas & company, Sora would've been screwed as well.
Kingpin Life Of Crime: the main character is brutally beaten by thugs working for Nikki Blanco, and he's told never to come back. Instead, he sets across the landscape, destroying the Mafia run businesses, killing numerous members, and going after Nikki's boss to finally take control for himself.
Kirby Squeak Squad. Cake is stolen? Go beat up Dedede! Dedede doesn't have the cake, but some thieves do? Go beat them up! Treasure chest does not contain cake? Beat up the thing that's in it!
Laura Bow: The Colonel's Bequest: The actual good ending tells you that Lillian did this.
Legacy of Kain: Soul Reaver: The vampire Raziel is brutally mutilated, rebuked, and tossed into oblivion...but that's just how the story starts. Once he gets back up, Raziel gets to work his way up through his younger brothers, leading straight up to Kain himself.
This is something of a running theme in the Legacy of Kain series. First game opens with secondary character Vorador slaughtering six of the most powerful people in the world out of revenge; the game itself is Kain's rampage of revenge. In Soul Reaver 2, Raziel goes on another one against the mortal forms of himself and his brothers in the past, and Blood Omen 2 features Kain on yet another rampage.
Liara T'Soni becomes obsessed with Shepard to the point where she is willing to work with Cerberus after the Collector attack. When the Shadow Broker tries to sell Shepard out to the Collecters Liara does not take it well, and starts working with criminals, Asari commandos, threatening to kill her contacts with their own spine, all to get back at the Shadow Broker. When she finds out that her friend Feron, who was captured and presumed killed by the Shadow Broker, is alive, however, her motive rapidly change from revenge to rescue...with a revenge flavor.
Zaeed has a similar motive against Vido Santiago, and it is an implied part of Commander Shepard's backstory if the Colonist background is combined with a Ruthless reputation.
Thane Krios Has one of these in his back story. When his wife, who he had met by having her interpose herself between his gun and his target, is assassinated by slavers trying to strike back at him; he snaps and hunts them ALL down:
Thane:"I was taught to grant death quickly, cleanly, to minimize suffering. Them, I let them linger."
Could be a trait of Asari. The UnfetteredCombat Pragmatist Aria gets kicked out of her home base on Omega by Cerberus in Mass Effect 3, but doesn't really care about an intricate plan to get back at them:
Shepard:"How do you plan on getting Omega back?"
Aria:"I think I am going to employ violence."
Garrus's men (when he was Archangel) are this as well.
Shepard storming Cerberus headquarters near the end of the game considering how they constantly manipulated him/her in the previous game and tried to destroy all of his/her efforts for the war in 3. Especially when s/he guts Kai Leng.
Max Payne: The title character goes on one of these after his partner, Alex Balder is killed and he is framed for it. He starts with Jack Lupino, the guy he considers responsible, moves on to Lupino's boss, Punchinello, and then sets his sights on Nicole Horne when it's discovered that she was behind not only Alex's murder and the frame up (pulled off by dirty cop and Dragon B.B.), but also the murder of Max's wife and baby girl by V-head junkies three years ago.
And Max Payne 2 picks up before he starts his rampage. It isn't until the 3rd and final chapter of the game that he goes from reactionary, self-defense killing to actively hunting down those who wronged him. And everybody dies.
The third game continues the theme: Max is hired as a private bodyguard in South America. When his charge is kidnapped despite his best efforts, Max is told that he can't go up against the criminal cartel, there's too many of them and they have too much power. Max gears up anyway.
Mercenaries 2: Ramon Solano, the Big Bad, might have come out on top, had he not pulled a You Have Outlived Your Usefulness on the player merc, triggering a rampage across Venezuela that results in countless VZ casualties, billions of dollars in property damage, one destroyed castle, a few leveled cities, and two nuclear strikes.
Super Metroid: The final battle against Mother Brain depicts her destroying the Metroid Larva, which was trying to protect Samus in the first place. As it dies, it gives Samus the Hyper Beam, an insanely-powered, wall-piercing rainbow gun. So Samus, after being thrown around by Mother Brain like a chew toy, turns the tables and goes on a rampage against her, reducing Mother Brain to dust, and the planet Zebes soon after.
Metroid: Other M adds another level to it by giving it a cutscene to show just how pissed off Samus really was.
Practically every encounter she has with Space Pirates, particularly Ridley, could turn into a Roaring Rampage of Revenge. In the backstory, they destroyed the colony where she lived and killed everyone else, including her parents (one of whom was ripped apart and eaten by Ridley right in front of her). Yeah, the Pirates have a damn good reason to be afraid whenever "The Hunter" shows up.
Mortal Kombat: This game has a lot of characters with revenge as a motive. The best known probably being series mascot Scorpion; a spectral ninja whose story in the first game revolved around killing Sub-Zero, the man who killed him, his clan, and his wife and son. As it turns out, Sub-Zero only killed Scorpion; his family and clan were killed by Quan Chi, the sorceror who allowed him to seek revenge against Sub-Zero. When Scorpion finds this out, he switches targets to seeking revenge on Quan Chi.
Kung Lao is the first to discover Liu Kang's body in Deadly Alliance after the eponymous pair snap his neck. He vows revenge against the duo and seeks an old master to train for their defeat. It doesn't end well for him either, in spite of that. The roles are reversed in Mortal Kombat 9, wherein Kung Lao successfully defeats every challenger Shao Kahn puts before him until Kahn himself simply walks up behind him and breaks his neck. Liu Kang then challenges Kahn and this time puts a fiery fist right through his chest.
Ninja Gaiden: Although he remains chillingly calm about it, the remake is all about Ryu Hayabusa putting his blade through the many minions of the Vigoor Empire that razed his village and killed off almost all of his kin.
However, because of the way the UAA functions, the game serves as a deconstruction of the "work your way up to the big bad" plot. Travis' target is rank 1 in the UAA, so Travis has to slaughter a whole bunch of people to face him, almost all of them of them people he's never even met. By the time he can actually face his target, he's grown disgusted by all the kiling and swears vengence not just for his dead freind, but for all the people he's had to kill, vowing to bring down the ranked assassination scene and stop the mindless bloodshed.
Prototype: To quote Alex Mercer: "NOTHING CAN PROTECT YOU FROM ME! NOT MEN! NOT WEAPONS! NOT ARMOR!". And the guy about to get consumed? Was a jerkass, but definitely not at the top of Alex's hit list.
Prototype 2 starts going on the same venue: the new protagonist James Heller has lost his family to Blacklight while he was overseas and goes on a rampage in the infected zone to get himself killed. Unfortunately for him, Alex finds him dying and injects him with the virus, transforming him into the same Super Prototype as himself. Needless to say, James doesn't take it well.
Quintessence - The Blighted Venom: Reivier Wirt goes on a killing rampage after his wife supposedly dies. Complete with Hidden Eyes.
The Reconstruction: Dehl goes on one in chapter 6 after having a Freak Out that causes his personality to invert. This temporary personality change makes some of his skill descriptions read almost like black comedy.
"The serene, peaceful nature of the knight manifests in enhanced inner traits."
Saints Row 2: The latter part of the Brotherhood storyline (for both sides), an excellent example of why having someone actually roar and rampage is a lot better than being calm and deliberate when your the one they want revenge on.
A large part of the plot of Saints Row The Third is about revenge. The Saints are out to avenge the death of Johnny Gat, first targeting Philip Loren, before going after Killbane. The individual members of your crew are motivated to avenge some sort of wrong, and the ending you get depends on if you are willing to let your vengeance go, or pursue it at the cost of all else.
Sengoku Basara 3: Ishida Mitsunari is out to kill Tokugawa Ieyasu in revenge for his master. No matter what you do, no matter how hard you try, you will not be able to stop him. And God help you if you get in his way. He'll add you to the list.
Shenmue: The entire premise of the game is basically Ryo Hazuki seeking the man who killed his father, despite heartfelt pleas from Fuku-san, Ine-san and Nozomi-chan not to do so. He doesn't really think very clearly, gets in a heap of trouble frequently through ill-thought-out actions and goes after the more shady inhabitants of Yokosuka and Kowloon with varying degrees of competence. However, if you kidnap someone he's close to, then prepare for pain. One time he kicks the living crap out of 70 people to get fix things.
Sins of a Solar Empire: You have an entire star nation going on a Roaring Rampage of Revenge; the Advent. You see, the Advent's ancestors were a religious order on a remote desert planet that was experimenting with cybernetic implants and Psychic Powers in an attempt to unite humanity in a peaceful coexistent society when they were found by the Trade Order. The Xenophobic Trade Order, which decided the Advent were too different to coexist with the rest of human society. So they exiled the Advent into deep space without first taking away or destroying their psychic and cybernetic research. Predictably, the Advent continue to develop those technologies and build a formidable empire with a large fleet of some very powerful warships outside Trader space; all the while brooding over their mistreatment and exile. A few generations later the first Advent fleets cross back into Trader space intent on reclaiming their homeworld and punishing the Trade Order (now known as the Trader Emergency Coalation-TEC).
Sonic the Hedgehog series: Shadow's response to Maria's death. First against humanity (stopped by Amy), then in the true ending of Shadow the Hedgehog directed against Black Doom. In his Crowning Moment of Awesome he doesn't stop with killing Black Doom. No, he proceeds to massacre the entire Black Arms army to a man with the Eclipse Canon.
Sonic Generations (360/PS3) players who have played Sonic Adventure 2 will recognize the infamous City Escape GUN truck. Not only is it back to get back at Sonic, but it has since equipped itself with buzzsaws and jet boosters. All just to catch one hedgehog!
Splinter Cell: Conviction: The entire premise is centered around Sam Fisher's hunt to avenge his daughter's murder. Except she wasn't murdered. Her "death" was engineered by Lambert in order to focus Sam on a specific mission. Grim is manipulating Sam with the knowledge that his daughter is alive, in an attempt to get him to help her stop a military coup in the US. Sam agrees, but when the job is done, he makes it clear that if anyone from his past contacts his again, he won't be merciful. And then, in the ending, when his friend is relating the tale to the Black Arrow mercenaries that have captured him, the base is rocked with explosions, as Sam goes to save the last friend he has...
Starcraft: Sarah Kerrigan, over a dozen planets later and she's still getting warmed up. Well, there goes the universe!
In Starcraft II, after the events of Wings of Liberty Kerrigan seems more focused specifically against Arcturus Mengsk, who she deems to have subjected her to a Fate Worse than Death all the way back in the first game.
Star Wars Battlefront II: Imperial Campaign. It's right after the Battle of Yavin. The Rebellion has destroyed the Death Star, killing untold numbers of your fellow servicemen. Your mission? Payback time. You're going to wipe out every last one you can find and blow their base to bits.
Submachine 8: The Core: all the devastation in the Winter Palace is revealed to have been Murtaugh's fault, because the death toll from his Portal Network tearing everything apart led those affected to those in charge attempting to bury him in the Lighthouse; this didn't turn out so well for those in charge.
Suikoden II: Despite the fact that he is probably one of the most reprehensible villains in video game history, Luca Blight could use this as justification for his actions.
Works for me; it's the only humanizing quality about what would otherwise be an almost cartoonishly evil villain.
Super Robot Wars: After finding out that the Fury basically obliterated everything near her in the beginning of the series, Calvina Coulange in Super Robot Wars Judgment fell into this trope, intensely hating every Furies she came across and mercilessly slaughtering all Furies that come across her, but she didn't do it with a roar. She later made one exception, though.
Also, Fallen Hero Tempest, whose family were killed by the EFA screwing up, and who has joined the Divine Crusaders not to protect the world from aliens or build an empire, but simply to hurt the EFA. As it happens, he doesn't give a damn about the "list", attempting to kill a fourteen-year-old girl despite noting that she was the same age as his daughter would have been.
Tales of Legendia: Chloe Valens heads to the the Legacy in order to track down her parents' killer, a man with a snake tattoo. Any time she even sees his face she flies into a fury.
Tales of Symphonia: Kratos has an epic one when your party fights Kvar, stabbing him and then slashing him in the chest twice, due to what Kvar did to Anna.
Team Fortress 2: An unlockable shotgun for the Engineer allows you to avenge your turret, giving you two guaranteed Critical Hits for every kill the turret made while it was still around, and one for every kill assist.
Near the beginning of Thor: God of Thunder, a game set before the events of Thor itself, Sif pushes another Asgardian out of the way of danger. She is then impaled and becomes dead for a time, enraging Thor and causing him to seek vengeance for her death.
Odin:(discussing bringing Sif back to life and messing with fate) I may yet forestall slaughter and holocaust.
Loki: Your gift to him will surely slake his vengeful thirst, and while you recover in the Odin sleep, I know he will defend Asgard in your stead.
Touhou: You do NOT mess with Yuka's flowers. Your life will become VERY short.
Traffic Department 2142: In this DOS game, the main character Lt. Velasquez has been on one of these ever since her father was killed. As the game goes on, her hatred builds, sending her on a downward spiral towards the Moral Event Horizon, before she finally "finds peace" in the form of even her being too tired of killing to go on doing it.
True Crime: Streets of LA: The game has an optional story arc in which Nick Kang, on failing to rescue his brother, himself goes on a roaring rampage of revenge to find and kill the man responsible, having already been slightly pushed over the edge by the death of his father prior to the game's beginning. Said rampage leads to one of the "bad endings" in the game, since Nick is left with unanswered questions regarding his own father's fate - the secret dies with the endgame boss.
Tsukihime: Arcueid Brunestud's kill list: #1: Michael Roa Valdamjong, whenever possible and as much as possible until he stays dead, damnit. #2: Dead Apostle Ancestors, so another 20 or so on the list. #3: Normal Dead Apostles, Demon Lords, people like the Church who get in her way.
Kohaku's hero status is rather debatable but her targets go like this: Makihasa (done) Akiha and SHIKI (done in two out of five possible endings, SHIKI in all of them. Then maybe Shiki and anyone else related to the Tohno family she can think of.
Viking Battle For Asgard: They just start piling up very quickly. Rakan joins Hel in destroying the world because Freya spurned him, Skarin goes on his own by fighting his way (offscreen) to Fenrir and releasing him when Freya essentially enslaves him, and Fenrir himself gets one against the Gods for chaining him up in the first place.
Wet: Rubi is set up by Rupert Pelham, who is in charge of a global drug ring, to take the fall for killing William Ackers's son. How does she get even? This is the page for Roaring Rampage of Revenge, what do you think?
World of Warcraft: Jaina Proudmoore goes on one after the Horde destroys Theramore, and has to be talked down from destroying Orgrimmar in retaliation. Later, when she's made leader of Dalaran, one of the few places where the Alliance and Horde still coexist peacefully, her trust is betrayed when the Blood Elves use Dalaran as a jump point to invade Darnassus; she to purges the Horde from Dalaran and devotes it and the Kirin-Tor to the Alliance.
X3 Albion Prelude: The entire plot of the game revolves around the Terran's roaring rampage of war and revenge after the Argon Federation blows up the Torus Aeternal, a massive orbital shipyard / city for tens of millions / defense installation that wraps entirely around Earth.
Xenogears: Id goes on one of these after the villains try to kill the woman he...well, he doesn't exactly love her, but he considers her to be his. He ends up destroying an entire floating city and causing the deaths of at least thousands of innocent people.
To put this in perspective, the city is designed to utterly destroy a full assault from the entire military forces of the rest of the world combined without so much as causing a cup in the city to quiver. Id ripped through the entire city with full defenses operational and firing in roughly ten minutes.
XIII: While it's only a side goal and you'd much rather just take out their head, you still get a list of the conspirators. This is kind of interesting at first as everyone on the list but your traitorous self, even the lowest rankers, are bosses for the first 85% of the game, and it seems like the game is setting up an all-boss rampage like some of the excellent examples above. Unfortunately, you end up killing about half of them in the second last stage, dressed in Klan outfits and equipped with no more AI or HP than the average mook. Oh, and the leader escapes to the sequel that will never be.
Zyll: Zyll didn't hesitate to embark on this once he discovered the Black Orb.
A particularly brutal deconstruction of this trope is present in Red Dead Redemption. The protagonist John is shot and killed in the ending by the corrupt cop Edgar Ross, prompting his grown-up son Jack on one of these for the game's epilogue. Here's where the deconstruction comes in: before John's death, Jack was a kind-hearted, idealistic young man with dreams of becoming a writer. Afterwards, Jack becomes a jaded gunslinger outlaw on the run from the government, drifting from place to place with his former life in ruins. While he eventually succeeds in getting revenge on Ross, it doesn't matter in the end, because Ross is remembered as a hero, John is remembered as a brutal criminal who was brought to justice, and Jack has to spend the rest of his days as a depressed, wandering loner, trapped in a gun-slinging lifestyle that is quickly dying out. Damnit.