As an iconic show, some actors and actresses who had bit parts in The Sopranos would go on to become much more famous in other movies and TV series.
- Michael K. Williams has a brief appearance in "Army of One", about a year before his turn as Omar Little on The Wire launched his career.
- J.D. Williams has a bit role as a gangbanger in "46 Long", a little while before getting the more prominent roles of Kenny Wangler in Oz and Bodie in The Wire.
- Major Carl Zwingli (the principal of Hudson Military Institute in "Army of One") is played by Tobin Bell, who would later become known for his iconic role as Jigsaw in the Saw movies.
- The doctor who diagnoses Phil Leotardo in "Kaisha" is played by Aasif Mandvi, who had yet to become well-known for his appearances on The Daily Show.
- A fifteen-year-old Stefani Germanotta — who would later become known to the world as Lady Gaga — briefly appears in "The Telltale Moozadell" as one of the girls watching A.J. and his friends vandalize the Verbum Dei swimming pool.
- An eighteen-year-old Paul Dano appears in two episodes as A.J.'s friend Patrick Whalen.
- Will Arnett appears in 2 episodes of Season 4 as (the relatively quiet and kind) FBI agent Mike Waldrup, roughly a year before Arrested Development began airing and he became known for playing bombastic, Jerkass characters.
- Tony Hale, also of Arrested Development fame, would make a brief appearance in "Second Opinion" as a nurse who helps Junior.
- C.S. Lee makes an appearance as the ER doctor who operates on Tony after he's shot in Season 6. He's best known now as Vince Masuka in Dexter.
- Prolific character actor Bokeem Woodbine was still fairly early in his career when he appeared in "A Hit is a Hit" as Massive Genius. He's perhaps best known today for his turn as Mike Milligan in season 2 of Fargo.
- A 12-year-old Michael B. Jordan appears in a flashback in "Down Neck" as one of the kids who hassles a young Tony for littering.
- Lin-Manuel Miranda has a 2-line role as a hotel bellhop in "Remember When".
- Michael Kelly has a small role in the later seasons as FBI Agent Dwight Harris' partner years before he became more recognizable from House of Cards (US) as Doug Stamper.
- Alysia Reiner has a small role as the prosecutor on Johnny Sack's case in "Mr. & Mrs. Sacrimoni Request", long before Orange Is the New Black made her recognizable as Warden Natalie "Fig" Figueroa. She's replaced by another actress in later episodes.
- Cristin Milioti has a few scenes as Johnny Sack's younger daughter in season 6.
- Selenis Leyva has a brief scene as Vito's mistress in "Live Free or Die" before raising her profile as Gloria Mendoza in Orange Is the New Black.
- Ken Leung appears in "Remember When" a year before becoming a cast regular on Lost.
- Catherine Dent and Paula Garces, both better known for their roles as Officers Danielle Sofer and Tina Hanlon in The Shield, make appearances in "Do Not Resuscitate" and "Unidentified Black Males" respectively.
- Kevin Sussman appears in "Guy Walks Into A Psychiatrist's Office" as the unfortunate broker who gets pummeled by Matt and Sean for not participating in the pump-and-dump scheme, nine years before he became Stuart in The Big Bang Theory.
