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Homer wakes up in the snow with no memory of the night before. When he comes home, he finds that his family is missing, Chief Wiggum came over due to a domestic disturbance, and Moe gave Homer a drink called "The Forget-Me Shot," which causes memory loss and is only drunk by people who have a bad memory they want erased.

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!!Tropes:
* BrainBleach: Moe's special drink has this effect.
* ClipShow: A subtle one. Homer's trip through his mind has a TV wall featuring clips from past episodes.
* CountinuityCavalcade: Towards the end of the "Picture a Day for 39 Years" sequence, a rapid fire montage of Homer in various outfits and costumes he has worn throughout the series was shown, such as his town crier hat from "Lisa the Iconoclast", the Safety Salamander suit from "See Homer Run", his GodGuise from "Kiss Kiss, Bang Bangalore", his Civil War reenactment costume from "The Sweetest Apu", the giant novelty hat from "Homer and Apu", his tribal chief costume from "The Bart of War", and more.
* CutHimselfShaving: Marge claims that she got her black eye from running into a door. Wiggum doesn't believe her, stating that this was a stupid excuse... [[TemptingFate only to run into a door himself]].
* {{Denouement}}: The entire gambit plot is explained at the end on the party boat.
* FalseMemory: Played for laughs. Bart destroys Homer's memory of his first kiss and make him believe it was with Apu.
* FunWithAcronyms: The '''M'''emory '''R'''ecovery '''I'''nstitute, with the disclaimer out front: we do not do [=MRIs=].
* GambitRoulette / MemoryGambit: Homer pulls one on himself. Upon accidentally learning that Marge was planning a surprise party for him, he goes to Moe's and orders an amnesia-inducing drink. Before he downs it, he predicts that he will wake up to find his family missing, remember snippets that imply that he hit Marge, go to Dr. Frink for memory recovery, only remember enough to conclude that Marge was having an affair with Duffman, and then throw himself off a bridge at the exact moment in which the party ship was underneath and at the exact place in which he lands on the ship's moonbounce.
* HairTodayGoneTomorrow: The "Picture a Day for 39 Years" sequence shows Homer losing his hair in a time lapse.
* InterruptedSuicide: Homer tries to invoke this trope when standing on the suicide bridge but the driver passing by doesn't care.
* IronicEcho: Homer's line "The mother of my children with the reason for my children" changes its meaning in a funny way. First time around the "reason" is Duff Man (alcohol), but later Homer refers to Marge's caring nature as the reason.
* {{Jerkass}}: Patty and Selma, they push Homer off the bridge and then try to trick him into drowning himself in front of his family.
* JourneyToTheCenterOfTheMind: Homer's mind, to be more specific
* MistakenForCheating: Homer catching Marge with Duff Man.
* MyGodWhatHaveIDone: Homer when he thinks he caught Marge cheating on him and gave her a black eye in response.
* ObnoxiousInLaws: When Homer starts having second thoughts about jumping off a bridge, his sisters-in-law push him.
* OutOfContextEavesdropping: Homer's line explains it all: "I must be the only gullible husband who ever overheard snippets of surprise-party planning, and believed his wife was having an affair!"
* ParodyNames: The episode title is a pun on the movie title ''Film/EternalSunshineOfTheSpotlessMind''.
* RidingIntoTheSunset: The last scene of the boat floating towards the moonlight.
* ScarySurpriseParty: Homer's journey to track down the secret of his erased memories lead to a surprise party on a party boat.
* ShoutOut: A couple.
** The episode starts with [[WesternAnimation/IceAge a squirrel trying to get an acorn]].
** The chalkboard gag was "The Capital of [[HannahMontana Montana is not Hannah]]"
** The ClipShow, underscored by a tune by Music/YannTiersen, is an obvious homage to ''Film/{{Amelie}}''.
** [[Film/ItsAWonderfulLife The jump from the suicide bridge on a snowy winter's night]].
** [[Film/TheGame Homer falling to his death but landing on a giant airbag instead]].
** Moe spitting in Homer's drink that makes him forget everything is a reference to ''Film/{{Memento}}''.
* SuicideDare: One of the darkest jokes of the series, where Patty and Selma encourage Homer to kill himself by jumping off a bridge. It's averted when Homer decides to reconsider, but Patty and Selma push him off anyway.
* SureLetsGoWithThat: Homer assumes Patty and Selma pushed him because they knew about his MemoryGambit. They "confirm" it.
* TemptingFate: "Alright, let me just get out of this bubble-- smoothly and elegantly..."
* {{Theremin}}: The instrument can be heard when Homer gets into the bubble and into his mind.
* TimmyInAWell: Parodied when Homer tries Santa's Little Helper to help find his family via Map Quest, sorry, Google Maps.
* WhatDidIDoLastNight: Homer wakes up with no knowledge of last night and subsequently tries to put the pieces together.
* WholePlotReference: To the ''Film/EternalSunshineOfTheSpotlessMind'' movie.