Mr. Burns has The Simpsons house-sit for him while he goes to the Mayo Clinic, and Homer uses Mr. Burns' mansion and wealth to hold a booze cruise for his buddies.

* TheAlcoholic: Lenny tries to drink rubbing alcohol.
* BitingTheHandHumor: Homer calling out everyone in the credits over being richer than he is (including the voice actors, who aren't as rich as they should be, but still are richer than he'll ever be), except for Richard K. Chung ("Oh, he's poor.").
* ComicallyMissingThePoint: When Burns is informed of his "Three Stooges Syndrome", Burns concludes that it must mean he's indestructible. However, the Doctor tries to tell him that even a slight breeze could kill him, but Burns walks away satisfied.
* EnemyCivilWar: Mr. Burns suffers from a biological version of this. A doctor tells him he has every disease known to man, as well as new ones found inside him. However, they all get in each others' way, thereby preventing Burns from actually dying of anything
* HypocriticalHumor: When the ship is hijacked by pirates:
--> '''Lenny''': [[SarcasmMode Some party, Homer.]]\\
'''Homer''': Shut up, net-face.\\
'''Lenny''': Hey, you're in the net, too.\\
'''Homer''': I ''said'', shut UP, net-face!
* KnifeFight:
-->'''Homer''': Look at those poor saps back on land with their "laws" and "ethics". They'll never know the simple joys of a monkey knife fight. ''[Sure enough, two monkeys are fighting with knives while a cheering crowd watches]''
-->'''Moe''': Thrust! Parry! Stab, stab, stab! ''[one of the monkeys screams]'' Ha-ha! He ain't pretty no more!
* LoopholeAbuse: Homer would take Mr. Burns yacht to international waters just so Moe would be able to sell beer on a weekend before 2:00pm. Barney pointed out Moe could legally ''give'' beer. Moe doesn't budge.
* OffModel: According to simpsonsarchive.com, Britney Spears was drawn more like Baby Spice from The Spice Girls, though her character design was meant to look like Spears from her "Baby One More Time" video.
* OlderThanTheyLook: The search for Springfield's oldest resident reminded us of Ned Flanders' real age.
* TheOnlyOneAllowedToDefeatYou: Mr. Burns has literally every disease known by mankind and some that were unknown until a doctor examined him. The doctor says the diseases are fighting among themselves.
* PetTheDog: Mr. Burns isn't upset about losing his yacht, but he seems genuinely worried when he finds out about the injuries sustained by his ape.
-->'''Mr. Burns''': ''[horrified]'' Furious George! What have they done to your beautiful face?! ''[hugs the ape]'' There, there...[[{{Squick}} Smithers, this monkey's going to need most of your skin]].
* RiddleForTheAges: Exactly ''what'' laid God knows how many eggs in Smithers' brain.
* SelfMadeOrphan: When Mr. Burns filled a form, he had to inform his parents' cause of death. He wrote "Got in my way".
* TakeThat: When Homer moaned that he never got any award, Marge reminded him of [[Recap/TheSimpsonsS5E1HomersBarbershopQuartet his Grammy]], prompting him to say he meant an award worth winning. Then we're shown a disclaimer stating Homer's opinions don't necessarily reflect those of the network, [[BaitAndSwitchComment who doesn't consider the Grammy an award at all]].
** {{Irony}}: They made that joke on an episode that had someone who won a Grammy at the time of the episode's premiere (Music/BritneySpears)
* UnusuallyUninterestingSight: While Marge is cleaning Mr. Burns mansion, one of the rooms she tidies is his secret laboratory. She nonchalantly wipes dust away while ignoring the bizarre and horrific experiments around, including several jars containing clones of Burns and Smithers.