The episode begins with Peter announcing that they've been cancelled to make room for other FOX shows, like ''DarkAngel'', ''{{Titus}}''[[note]]which actually got canceled the same year as ''Family Guy'' under different circumstances -- i.e., Christopher Titus fought with the executives over having his character and Erin break up[[/note]], ''{{Undeclared}}'', ''Action'', ''That 80s Show'', ''Wonderfalls'', ''Fastlane'', ''Andy Ricther Controls the Universe'', ''Skin'', ''Girls' Club'', ''Cracking Up'', ''The Pitts'', ''{{Firefly}}'', ''Get Real'', ''[=FreakyLinks=]'', ''Wanda at Large'', ''Costello'', ''The Lone Gunmen'', ''A Minute With Stan Hooper'', ''Normal, Ohio'', ''Pasadena'', ''Harsh Realm'', ''Keen Eddie'', ''The $treet'', ''American Embassy'', ''Cedric the Entertainer Presents'', ''The Tick''[[note]]The live-action sitcom, not the 1990s cartoon, though both got ScrewedByTheNetwork after a short run on FOX[[/note]], ''Luis'', and ''Greg the Bunny''[[note]]which, coincidentally, had Seth Green on it[[/note]]. Peter then reassures Lois that if all those shows got canned, then ''maybe'', they'd get a second [[note]](or, third, if you count the brief 2000 cancellation)[[/note]] chance.

...And they do.

We then get the story, where it kicks off with Peter and Lois going to get a second honeymoon, but Peter screws it up because he reads an Archie comic while driving. They end up at the Park Barrington Hotel, where Peter masquerades as Creator/MelGibson so that he and Lois can get into the hotel, where they find that Mel Gibson is going to make ''Film/ThePassionOfTheChrist II'', and take the film reel so that they can destroy it.

!!"North By North Quahog" contains examples of:
* DisneyVillainDeath: Mel Gibson.
* EpicFail: Peter ''forgetting how to sit down''.
* LongList: The list of canceled shows that came on around the same time as or after ''FamilyGuy'' was canceled from 2002 to 2005 (a lot of which were mediocre to awful shows that were canned for low ratings and negative reviews, like ''That 80s Show''[[note]]though that show would more or less live on as ''ItsAlwaysSunnyInPhiladelphia'', as Glenn Howerton, Charlie Day, and the actress who plays Corey's bisexual ex-girlfriend would be on that show[[/note]], ''The Pitts'', and ''Cedric the Entertainer Presents''. Some, like ''Titus'', ''Undeclared'', all of Joss Whedon's shows (''Firefly'' and ''Dark Angel''), ''Greg the Bunny'', ''The Tick'', ''Wanda At Large'', and ''Action'' were fairly good shows that merely got ScrewedByTheNetwork due to timeslot changes, ExecutiveMeddling, or FOX not advertising the show enough for people to take interest).
* TakeThat: When Meg asks Chris to turn the channel to ''TheGeorgeLopezShow'', Chris says the show perpetuates the stereotype that George Lopez is funny.
* {{Uncanceled}}: The beginning of the episode.
* WasTooHardOnHim: Stewie asks Brian this when he spanks Chris after catching him with vodka, despite that Chris was framed by a student.
-->'''Stewie''': Do you think we were too hard on Chris tonight?\\
'''Brian''': What? Oh, God. No, no. I don't...I don't think so. Do you?\\
'''Stewie''': Oh, no, I just always feel badly when we have to be strict.