'''Original air date''': November 27, 2005

Lois discovers that she has a brother (voiced by Creator/RobertDowneyJr), who has been locked in a mental hospital after a traumatizing experience he suffered as a child. Meanwhile, Peter starts an advocacy group for fat men after Dr. Hartman diagnoses him with "being fat."

!! Tropes associated with this episode

* BrickJoke: During a meeting of fat guys in the Griffon's living room, Stewie starts impersonating a carnival barker seeing who can find his penis first and win one dollar. Later, when the group band together to hunt down Patrick, one guy can be overheard saying "Hey, I found my penis!"
* ContinuityNod: Brian throws a rock at Peter for rolling up the window when he tried to jump into the General Lee in "To Love And Die in Dixie."
** WhatCouldHaveBeen: Originally it was going to be because Brian was in a carrier cage on a plane to meet Patrick and Peter pissed on him. Probably changed because Brian would ''never'' get into a carrier carriage.
* {{Hypocrite}}: Peter's meeting for fat people carries a sign reading "No Fat Chicks".
* ImplausibleDeniability: Lois absolutely refuses to believe that Patrick could be the Fat Guy Strangler. Brian shows her Patrick's room, where the walls are covered with pictures of strangled fat guys, the corpse of a fat guy, and a half-dead fat guy who says Patrick tried to kill him. Lois remains resistant to the brazenly obvious until Brian yells at her.
* InnocentlyInsensitive: Peter is a {{jerkass}}, but he had no way of knowing that Patrick was traumatized over Jackie Gleason. He still brainlessly does it again right after Patrick has been stopped.
* NotSoImaginaryFriend: Implied with Marian. Brian and Stewie leave a cucumber where in front of where she supposedly sits, and it pickles.
* OnlySaneMan: Brian realizes straight away that Patrick is the Fat Guy Strangler and tells Lois that it's pretty clear it's him. Lois however is in full blown denial.
* OverlyLongGag: Dr. Hartman's many fake-outs on whether Peter is healthy or not:
--> '''Lois''': So, Doctor? ls Peter healthy?\\
'''Dr. Hartman''': Goodness. You'll be dead in a month.\\
'''Lois''': What?\\
'''Dr. Hartman''': Hägar the Horrible, if you keep up that lifestyle of pillaging and turkey legs, you'll be dead in a month. Now, onto you.\\
'''Peter''': So what do you think? Pretty healthy?\\
'''Dr. Hartman''': Well, Mr. Griffin, let's take a look at your physical results. (screams; Lois and Peter gasp) There's a spider in here. Now, here we go. Mr. Griffin, you're going to expire in a month. (Lois and Peter gasp) This is your driver's license, isn't it? I'm afraid you are going to die... (Lois and Peter gasp) when you watch these Dean Martin celebrity roasts.\\
'''Lois''': Will you just tell us how Peter's health is?!\\
'''Dr. Hartman''': Mr. Griffin, I'm not quite sure how to say this. Kim Bassinger? Kim Basinger? But now, onto the cancer.\\
'''Lois''': My God.\\
'''Dr. Hartman''': You are a Cancer, right? You were born in July? On to these test results. My, they're much worse than I thought. (Lois and Peter gasp) My son got a D minus on his history test. Now, that liver's got to come out.\\
'''Peter''': What?\\
'''Dr. Hartman''': It's been in the microwave for three minutes. Now-\\
'''Lois''': Please. Please, we can't take any more shtick.
** The first meeting for fat people, which consists of a lot of belching, flatulence, heavy breathing, and unwrapping candy bars.
** Ball in a cup.
** "Pow! Right in the kisser!"
* ShoutOut: To:
** ''Series/TheHoneymooners'': The Jackie Gleason look-alike (and later, Peter) impersonating the show's signature character and mannerisms, including "Pow! Right in the kisser!"
** Music/BillyJoel: The "caveman who invented singing" performs Joel's 1984 hit "The Longest Time," a cappella style.
* ThisIsGonnaSuck: After Patrick introduces "Marian", Stewie merely sighs a deadpan "Oh, here we go...", knowing instantly things will go downhill from there.
* TraumaButton: Peter's insensitive impersonation of Ralph Kramden (from ''Series/TheHoneymooners'') triggers Patrick's trauma of seeing his mother and a Jackie Gleason lookalike having an affair ... and sets off his homicidal rage against overweight people.