In this BizarroEpisode, the Griffins are the sole survivors of the apocalypse caused by the Y2K computer virus and head off to Natuck to rebuild society near a Twinkie factory.
* AfterTheEnd: The Setting.
* {{Irony}}: [[LampshadeHanging Lampshaded]] and [[DiscussedTrope discussed]] by two random guys when Octo-Stewies overrun the town after they get rid of the guns.
-->'''Random guy:''' Hey Bob, you remember the other day you were asking me what the definition of irony was and I said-
-->'''Octo-Stewie latches onto his face'''
-->'''Random guy:''' AHHHH!
* WeaponizedOffspring: The nuclear holocaust mutates Stewie into a half-human-half-octopus creature, who then lays a huge pile of eggs. Next scene, an army of human-octopi march through the town chanting "victory is ours", and attack the people by jumping at them and grabbing their faces with their tentacles.