Wanda: What could possibly go wrong?
Darryl: You want that alphabetical or in likely order of occurrence!?
The Doctor: This is one of the safest planets I know, there is never anything dangerous here!
Discovers the planet is about to be covered in acid rain
The Doctor: There are some sentences I should just keep away from.
— Doctor Who, The Doctor, The Widow, and The Wardrobe''
"Eight years involved with the nuclear industry have taught me that when nothing can possibly go wrong and every avenue has been covered, then is the time to buy a house on the next continent."
"The major difference between a thing that might go wrong and a thing that cannot possibly go wrong is that when a thing that cannot possibly go wrong goes wrong it usually turns out to be impossible to get at or repair."
Geek Scientist: Look, we have medics and guards standing by just in case. And this is one of our strongest containment rooms. Everything is under control.
Joel: You do realize that the scientist say that in every horror movie, just before things go horribly wrong.
Geek Scientist: This isn't a cheesy B-Movie, Joel. Relax! What could go wrong?
Joel: Are you trying to get us all killed?
Isabela: I have a bad feeling about this.
Varric: "I have a bad feeling about this"? That's up there with "What could possibly go wrong?"!
Helicopter Pilot: Welcome to Itchy and Scratchyland, where nothing can possib-lie go wrong. Uh, possibLY go wrong. That's the first thing that's ever gone wrong....
— The Simpsons, Itchy & Scratchy Land
Busby: What could possibly go wrong?
Jon: I don't know, you're pretty safe with a Chapter One called 'Cheese Wheels of Doom', so i'm willing to wager that EVERYTHING COULD GO WRONG.
— Jon Tron, Bubsy Collection
Dr. Brown: I just don't think we're ready to launch the system. We still have to run tests on it.
Doctor Whooves: I know, but Cranky says we need it running as soon as possible. Besides, what could go wrong?
— My Little Portal, Episode 1