Wanda: What could possibly go wrong?
Darryl: You want that alphabetical or in likely order of occurrence!?
The Doctor: This is one of the safest planets I know, there is never anything dangerous here!
Discovers the planet is about to be covered in acid rain
The Doctor: There are some sentences I should just keep away from.
— Doctor Who, The Doctor, The Widow, and The Wardrobe''
Geek Scientist: Look, we have medics and guards standing by just in case. And this is one of our strongest containment rooms. Everything is under control.
Joel: You do realize that the scientist say that in every horror movie, just before things go horribly wrong.
Geek Scientist: This isn't a cheesy B-Movie, Joel. Relax! What could go wrong?
Joel: Are you trying to get us all killed?
Isabela: I have a bad feeling about this.
Varric: "I have a bad feeling about this"? That's up there with "What could possibly go wrong?"!
Helicopter Pilot: Welcome to Itchy and Scratchyland, where nothing can possib-lie go wrong. Uh, possibLY go wrong. That's the first thing that's ever gone wrong....
— The Simpsons, Itchy & Scratchy Land
Dr. Brown: I just don't think we're ready to launch the system. We still have to run tests on it.
Doctor Whooves: I know, but Cranky says we need it running as soon as possible. Besides, what could go wrong?
— My Little Portal, Episode 1
"What could possibly happen, going to an insane man who hates me and owns a bunch of swords?"
"Eight years involved with the nuclear industry have taught me that when nothing can possibly go wrong and every avenue has been covered, then is the time to buy a house on the next continent."
"The major difference between a thing that might go wrong and a thing that cannot possibly go wrong is that when a thing that cannot possibly go wrong goes wrong it usually turns out to be impossible to get at or repair."
"Well, my reaction, to be honest, was one of absolute dismay. I thought it was a terrible idea. My feeling was that the clone story was best left in the past. Don't get me wrong, I enjoyed those original stories and found the ending very touching and poignant, and I thought the Jackal was a hoot, but I felt that dredging up all that stuff again was a mistake. Mark calmly replied, "Give it a chance. You don't know all the plans we have lined up, and I think once you approach it with an open mind, you'll see that it can work."
Editor/Writer Glenn Greenberg on The Clone Saga
Busby: What could possibly go wrong?
Jon: I don't know, you're pretty safe with a Chapter One called 'Cheese Wheels of Doom', so i'm willing to wager that EVERYTHING COULD GO WRONG.
— JonTron, Bubsy Collection