Talon Karrde: I don't suppose [Leia] has a sister?
Han Solo: Not that I know of. Though with the Skywalker family you never know.
''Hope has so far refused to meet Nate. She was raised and trained for years by a man named Cable. This took place in the, uhm, future, and Cable is now dead. Nate is...Okay, Cable and Nate are the same person but from different dimensions. He looks like a younger version of the man she thought of as her father. I'm aware how this must sound.
Emma Frost: [telepathically] Attention, students! Will the fruits of the womb of Jean Grey, Madeline Pryor, Redd Dayspring or any other alias, clone, or permutation thereof please report to the Danger Room! [Speaking] That should count for about 70% of the student body. I hope you're ready for a long day!
Harry: You're related to the Malfoys?
Sirius: The pure-blood families are all interrelated. If you're only going to let your sons and daughters marry purebloods, your choice is very limited. There are hardly any of us left. Molly and I are cousins by marriage and Arthur's something like my second cousin once removed.
DAVE: (rose whos the john looking kid)
ROSE: (I think it's young Father-Grandad Harleybert.)
'...In what other book do you have a family tree that includes members like Magneto, greatest foe of the X-Men, who's there, because his two children, Quicksilver, and the Scarlet Witch, are Avengers, and the Witch was married to the Vision, an android built out of the inert body of Golden Age hero the original Human Torch, but with the brain-patterns of long-thought-dead hero Wonder Man, all put together by the evil robot Ultron, who himself was the inadvertent creation of Hank Pym, a.k.a Ant-Man... who himself was married to the Wasp, who became the template for the robotic Jocasta, built to become the bride of Ultron but who rebelled against the Avengers — that's ten characters with familial or pseudo-familial links right there, and I'm just scratching the surface.'
Kurt Busiek, Intro to Avengers vol.3
Eli: Wait, is Shepard technically family again?
Dara: Technically, since you and Lin are blood-brothers, and he's married to Serana, yes.
Eli: You ever get the feeling that someone in twenty years is going to try to do our genealogy and shoot themselves?
—The Spirit of Redemption, Chapter 146: "Inhalation"
"As far back as I can trace, my relatives were carnival folk, who were touring a place called "Hiroshima" in the summer of 1945. After that because of their lack of hair and skin they mostly married each other. And here I am!"
—Milo, The Oblongs.
"So their son will be your nephew. After you're wed to Cersei, of course. And you will be the king's stepfather and brother-in-law. When you marry the king, Joffrey's mother will become his sister-in-law and your son will be Loras' nephew? Grandson? I'm not sure. But your brother will become your father-in-law."
—Olenna Tyrell, Game of Thrones
Aversa: "What a convoluted family tree we make! More like a tangled shrub, in fact. I'm older than you, and yet I was adopted AFTER your birth. Hmm... I suppose in a way that makes you my older brother? How delightful!"
Male!Avatar: "I'm not your brother, and you know it."
Aversa: "Silence. The matter is settled... Big Brother."
—Fire Emblem Awakening note