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By the end of the week, the victim's very bones gnarl and warp. Any lingering similarity to human guise is vague at best. The resulting creature is no longer human — it is an entirely different species, divorced of mortal concerns. During the last stage of transformation, the skull assumes its final shape, elongating, flattening or caving in entirely. Many humans associate their face with their identity; this falsehood is the last thing to crumble during the metamorphosis. A fledgling vampire's dead organs may twitch and shiver for weeks afterward while adjusting to the newly found form, but by then, the personal horror of utter alteration is complete.
— The Nosferatu Embrace, Vampire: The Masquerade — Clanbook: Nosferatu (revised)

One page of the report displayed a sequence of photos of what was ostensibly the same person, identified as Giles Shapleigh, eighteen years old when detained in 1928. He'd been a handsome kid in the first photo, and if he had nothing to smile about when it was taken, you could at least see the potential for a roguish, cockeyed grin. By his twenty-fifth year, he'd visibly aged, his hair receded and thinning, and after seven years of captivity, he had the sullen look of a convict. By thirty, he was bald as a cue ball, and his skull had seemed to narrow. By thirty-five, his jowls had widened enough to render his neck almost nonexistent, giving him a bullet-headed appearance that she found all the more unnerving for his dead-eyed stare.
By the time he was sixty, with astronauts not long on the moon, there was nothing left to connect Giles Shapleigh with who what he'd been, neither his identity nor his species. Still, though, his transformation wasn't yet complete. He was merely catching up to his friends, neighbors and relatives. By the time of those Prohibition-era raids, most of the others had been this way for years — decades, some of them. Although they aged, they didn't seem to weaken, and while they could be killed, if merely left to themselves they certainly didn't die.
The Same Deep Waters As You, by Brian Hodge

Unlike the First Change that marks the point of no return for most Fera, the evolution of a human (or arachnid) into a full-fledged Anansi does not occur all at once. The pre-metamorphosis Anansi experiences a gradual rise in curiosity, as she notices details and patterns in the world around her to a greater extent than in her previous life. The soon-to-become Anansi also finds her emotions cooling as she grows more dispassionate and analytical in her feelings and actions.
Physical changes soon follow as the Anansi's body slowly transforms itself into one capable of achieving many disparate forms. The individual's tastes change; she loses the desire to eat for satisfaction and eats primarily for sustenance and to fuel the changes in her body. Her muscles undergo sporadic spasms and subtle changes manifest; hair may sprout of heretofore-bare portions of skin or swellings may move
under the skin. While these changes may seem terrifying to the young Anansi, more often the individual finds them fascinating, predisposed to accept them by the emotional and psychological changes that have already taken place. Simultaneously, the new Anansi learns to control her changes at will so they are not obvious to the uninitiated. Finally, the Anansi learns that she needs blood to power her changes, discovering the Hunger. While she can still eat food, she learns that her true need is for the blood of warm-blooded animals to power her change.
Werewolf: The Apocalypse — Player's Guide To The Changing Breeds

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