Dr. Orpheus: It craves... purity... it devours... purity... it seems to be... What the hell is this thing made out of?
Dr. Venture: Nothing.
Dr. Orpheus: (parental disapproval) Come on...
Dr. Venture: Alright, fine, I might have used a few unorthodox parts.
Dr. Orpheus: Just tell me one!
Dr. Venture: An... orphan...
Dr. Orpheus: A what?
Dr. Venture: (coughs) ...An orphan?
Dr. Orpheus: Did you say... an orphan!?
Dr. Venture: Yeah, a little... orphan boy...
Dr. Orpheus: It's powered by a FORSAKEN CHILD!?
Dr. Venture: Might be, kind of, I mean, I didn't use the whole thing!
— The Venture Brothers, "Eenie, Meanie, Minie... Magic!"
Just think of it, Smithers - I tried every tincture and poultice and tonic and patent medicine there is, and all I really needed was the blood of a young boy!
— Mr. Burns, The Simpsons, "Blood Feud" [Editor's note: It's not evil in context]
Knob: This is an eco-friendly truck. It has an experimental engine I've been working on. It's fueled by the blood of orphans.
Riley: You kill orphans? For fuel for your vampire car!? Hasn't God kicked them in the face enough?
Knob: No, no, they're quite willing to part with their blood if you give them a hug or two. Needy little urchins...
This is the eternal kingdom of Zeal, where dreams come true. But at what price?
— Doreen, Chrono Trigger
It is a monstrous thing, to slay a unicorn. Only one who has nothing to lose, and everything to gain, would commit such a crime. The blood of a unicorn will keep you alive, even if you are an inch from death, but at a terrible price. You have slain something pure and defenceless to save yourself, and you will have but a half-life, a cursed life, from the moment the blood touches your lips.
— Firenze, Harry Potter and the Philosopher's Stone
Eat up! The sushi's made of fresh orphan.
— Dick Roman, Supernatural
Do not be put off by the occult practice of stuffing the living into walls. It is the most efficient way of powering Anima, and should be considered a form of veneration: we honour them and they protect us... until they begin to leak out. Then it is time to stop honouring them.
— The Dragon, The Secret World
Davitch: The Controller is linked to the transmissions. The entire output goes to her brain - you're not a member of staff, so she doesn't recognize your existence.
Doctor: What's her name?
Davitch: I don't know. She was installed when she was five years old. That's the only life she's ever known.
— Doctor Who, "Bad Wolf"