The deal with Mephisto is symptomatic of a bigger problem for the character and the people who write him: the unwillingness for the character to become an adult...The reason why they don't think there's "drama" in marriage is because marriage is an aspect of real life, and they don't want the escapism of Peter Parker swinging through the air and stopping bad guys being infected with the drama of things that people have to endure in the real world... But the truth is the reader has grown up, got married, had kids, has relatives that die and they have to move on. The reader changed, but Peter Parker has not.
So, if you think about it, Spider-Man not only made a deal with the Devil, he actually came out of it pretty damn good! He gets his aunt saved, his buddy gets back to life, his identity is secured, he still gets to have a long term relationship with a damned supermodel back then and fool around with kinky sex-addicted cat girls now...Basically all Satan gets is the thrill of blinking some bridal photos out of existence.
Aaah...Ouch? I guess? So let that be a lesson, kids!
If you screw up and need to make a deal with the devil, make sure it's with the Marvel devil. That guy's no idea of what he's doing!