Scientist: Young man... I'm afraid you've suffered some of the worst of what our... mighty little friend, the atom has to offer! It can power a city... or level it!! Human-insect mutation is far from an exact science. But there are some things we do know... You'll grow! (tsk tsk) Become bigger!
Homer: If we learned one thing from The Amazing Colossal Man and Grasshopperus, it's that radiation makes stuff grow real big real fast!
Marge:But didn't Grasshopperus kill Chad Everett?
Homer: Only because he tried to reason with him.
And so, kids at home, remember, if you're looking to get radiation poisoning, and I cannot stress this enough, get it through the bite of an animal. Not a mister. It's the difference between amazing, crime-fighting abilities and massive organ failure.
Milhouse: So that's how it happened!
Martin: I would've thought being hit by an atomic bomb would've killed him!
Bart: Well, now you know better.
These days they blame the atom for everything. Bad health, bad crops, bad weather. Now it's grasshoppers.
— Soldier talking about giant grasshoppers in Beginning of the End.
That always pissed me off about Spider-Man. How Spider-Man got superpowers by being bitten by a radioactive spider. That is such bullshit. For starters, the odds of a random mutation being beneficial are astronomical, but more importantly, even if you did get one, you'd still have radiation poisoning!
The gamma laser toxic spill gave me powers. So I mostly fly around helping people understand what it's like to be dying of cancer.
That's the thing about, eh, especially Marvel. Marvel's all, "Radiation is AWESOME!" It's like back in the fifties. Like, no, no, that's not the lesson you want to teach kids.
— Down in Front on Spider-Man
Lang: What's the biological precedence for an energy projection system?
Vik: Could be from radiation.
Lang: What radiation?
Vik: The radiation that made them big.
He recovered consciousness to see Godzilla bearing down on him with all the fury of a mutant monster who's been woken by some idiot using an H-bomb as an alarm clock.
— Plan 7 of 9 from Outer Space