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Sarge: Oh no! That last lightning bolt fused the detonator! There's no way to turn this thing off!
Simmons: Can you do it manually?
Sarge: Impossible. I specifically designed it so that I wouldn't be able to defuse it.
Sarge: In case I fell into the wrong hands, and was brainwashed to help the Blues.
Simmons: Nice thinking, sir.
Grif: You had to get just one last asskiss in before we die, didn't you?
— Red vs. Blue Episode 43
"The defense system is perfect, Mark," (points at unfinished, missing self-destruct cut off station), "it'll even bury our mistakes."
- Dr. Jeremy Stone after nuclear bomb countdown has started in the (1970) movie Andromeda Strain
"It's what you'd call a failsafe. Except he only got as far as the "fail" part."
— Tobi, on Itachi Uchiha's attempt to keep Sasuke away from the speaker.
"Note: Need to implement this."
— The Hidden Valley Bunker Self-Destruct Terminal upon clicking "Cancel Self-Destruct Sequence", Fallout New Vegas
(chaos is wreaking havoc in Ponyville)
Twilight Sparkle: Don't worry, everypony! I've learned a new failsafe spell that will fix everything!
(Her horn glows, and a wave of light surrounds Ponyville. When it fades... nothing happens.)
Twilight Sparkle: My failsafe spell... failed! Now what do we do?
Spike: Umm, give up?
My Little Pony: Friendship Is Magic, The Return of Harmony: Part 1