Sarge: Oh no! That last lightning bolt fused the detonator! There's no way to turn this thing off!

Simmons: Can you do it manually?

Sarge: Impossible. I specifically designed it so that I wouldn't be able to defuse it.

Grif: Why?

Sarge: In case I fell into the wrong hands, and was brainwashed to help the Blues.

Simmons: Nice thinking, sir.

Grif: You had to get just one last asskiss in before we die, didn't you?

— Red vs. Blue Episode 43

"The defense system is perfect, Mark," (points at unfinished, missing self-destruct cut off station), "it'll even bury our mistakes."
- Dr. Jeremy Stone after nuclear bomb countdown has started in the (1970) movie Andromeda Strain

"It's what you'd call a failsafe. Except he only got as far as the "fail" part."

— Tobi, on Itachi Uchiha's attempt to keep Sasuke away from the speaker.

"Note: Need to implement this."

— The Hidden Valley Bunker Self-Destruct Terminal upon clicking "Cancel Self-Destruct Sequence", Fallout New Vegas

(chaos is wreaking havoc in Ponyville)

Twilight Sparkle: Don't worry, everypony! I've learned a new failsafe spell that will fix everything!

(Her horn glows, and a wave of light surrounds Ponyville. When it fades... nothing happens.)

Twilight Sparkle: My failsafe spell... failed! Now what do we do?

Spike: Umm, give up?