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Precision F Strike:
Doonesbury The author pushed to allow B.D. to swear ("SON OF A BITCH!") when he wakes up after losing a leg in Iraq. This is significant because newspaper comics have extremely strict clamps on their subject matter. A few papers dropped the strip, most simply edited the line; a few kept it as-is, with the paper's editor stating it was justified.
Melissa saying "That's sergeant bitch to you", which seemed to just be for the sake of the punchline.
The 15th July 2010 strip of featured Pig's sole Pearls Before Swine direct use of note Symbol Swearing as a Take That against British Petroleum . He even said that he's "never said a bad word in the strip before".
note Believe it or not, came audaciously close to this trope in 1986:
Calvin and Hobbes [Calvin hands Hobbes a book.]
Calvin: What does this word mean?
Hobbes: Which one?
Calvin [pointing] That long one.
[Hobbes sees the word - and his eyes bug out, he claps his paw over his mouth, he jumps into the air, and his fur goes all bristly. Finally, he relaxes.]
Calvin: You do too!
The only time there was actually a curse spoken in the strip was also 1986, where upon seeing that "Be" only got him two points in Scrabble, Calvin states "2 POINTS? IS THAT @#$% ALL?", which was just done to have Hobbes say "My, this game does teach new words!".