Straight: Alice is the creator of a strange TV series that Bob insists had to be made while high. Alice proves she has never consumed any drugs at all; her mind just works that way.
Exaggerated: Alice made a work that seems straight out of an acid trip/Zardoz (is there a difference?). She is a devout and observant Mormon.
Downplayed: Alice was drunk when she conceived the premise, but sober while she actually made the work that executed it.
Alice has schizophrenia.
Alice used references, such as random thoughts that she got or her (self-admittedly) strange fetishes, that she could twist and intertwine carefully into the medium that causes the question to be asked.
The trippy show was made after getting sober/getting off some prescription drugs.
Subverted: Alice wasn't high while making the show...which isn't to say she doesn't partake.
...But she was high for that one episode Bob is asking about.
Yes, she is on drugs: they calm her down and help her focus on her work. Which is truly crazy stuff.
Parodied: Alice's work is an incredibly obvious Author Tract about the benefits of mind-altering drugs, down to the disjointed, psychotic narrator calling it LS...C. She still insists she doesn't do drugs.
Zig Zagged: The TV show is weird from the start, but initially Alice doesn't use drugs. She goes a bit insane from her fame and starts taking drugs to cope with the insanity. Ironically, the show gets a little more normal. She gets better and quits drugs, but the show gets crazier when she quits.
Averted: Alice isn't on drugs, and her TV show isn't weird at all.
Alice works just to get the feeling that the creation was an acceptable alternative to hallucinogens.
Alice is a fan of Lewis Carroll's style, as well as her parents apparently, but has any number of reasons not to use drugs, so she finds alternate ways to provoke oddness into ideas.
Exploited: Alice uses the weirdness of her show as an excuse to use drugs.
Defied: The show is mostly normal, despite the fact that Alice uses mental exercises to get strangeness into her ideas.
Discussed: In an interview, the creator says, "You know, this whole 'was my work made on drugs' type inquisition is really nothing more than a way to punish creativity by saying my mind must have been under chemical influence."
Conversed: "Hold on, you're telling me that Dalí never did anything stronger than Camembert cheese? Get outta here!"
Reconstructed: Alice states in interviews with with entertainment news sources (e.g. Entertainment Weekly or some Fictional Counterpart thereof) that she doesn't use drugs; her mind just works that way. Moral Guardians catch wind of these interviews and, now knowing the truth, they shut up.