Deconstructed: Alice's obsession with pleasing people who dislike her takes a toll when she focuses so much on Bob that she starts to ignore the people who already liked her. This causes her to lose all of her friends.
Reconstructed: After a while, Alice realizes that she can't please everyone and stops trying to make Bob happy.
Played For Laughs: Everyone hates Alice, but she takes the news that Bob dislikes her as a personal assault.
Played For Drama: Alice has a crippling personality disorder that won't allow her to accept the fact that people might not like her. Therefore, when she learns that Bob isn't fond of her, it tears her up inside.