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Zig Zagged: Some items drop every time (Rabbits' Feet), some drop randomly for no apparent reason (Bear Asses), some drop randomly for a good reason (Goat Bezoars), some only drop in specific circumstances (Wolf Pelts must be undamaged) and some drop even if you don't kill the animal (Lizard Tails fall off if you scare them).
Averted: Every time you kill an animal, any game-relevant body parts you'd expect them to have will drop.
Conversed: "So, it's taken me 60 dead bears to find 20 Bear Asses. On the plus side I have 60 of these Bearskin Rugs I can do what I like with..."
Plotted A Good Waste: There are ever-so-subtle differences between the bears which drop Asses and the ones which don't. Each time you find one, you gain Experience Points in Hunting which make the differences clearer. Hunt accurately enough (or just grind at it enough), and you become a skilled hunter, making future Fetch Quests more lucrative.
Played For Laughs: Your sidekick mocks you every time you fail to find an Ass.
Played For Drama: You're searching for a Unicorn Horn, and every unicorn you kill pushes you further down the Karma Meter. There is a counterintuitive way of getting a horn without killing any, and this is explained to you at length once you finally deliver the goods.
Back to Random Drop. Did that link work? Oh. Random Drop. Random Drop. Random Drop.