Parodied: Dying to the weakest mook in the game results in a joke montage of them uniting and taking over the world. Alice cuts off the scene with "No, that is bullshit, but still, how did you lose to them?! Evulz didn't even make them for labor, much less combat!"
Enforced: "We wanted to prevent the Artifact of Doom's overuse, because it makes the game way too easy. Let's have it turn Hiro into a colossal douchebag who makes even Evulz flinch through the sheer magnitude of his deubachery, and then end the game early!"
Lampshaded: "Yes, I know I screwed up. How much are you going to rub it in?!?"
Gamer 1: What on earth did Hiro just do? Did he just turn into the villain?!
Gamer 2: Relax. It's not a canon plot twist, it's a game over that incorporates a plot twist never to be mentioned elsewhere. Want to see another, even better event like that? Hand me the controller for a sec...