Lampshaded: "OK, Alice saves. Everyone else take 2d+4 damage."
Invoked: Seamus has a new Tsundere girlfriend, who has never played D&D before.
Exploited: Bob forms an alliance with Alice, so he can win along with her.
Seamus refuses to give anyone special treatment, because it will ruin the game.
The girlfriend refuses to let Seamus give her any special treatment.
Discussed: "How come she always wins?"
Conversed: "Because she's his girlfriend. La-dee-dah."
Deconstructed: This obvious favoritism ruins the dynamics of the table. Personal relationships should be kept out of RPG, especially if (let's say) Seamus is a much better/more experienced player than his girlfriend. Otherwise, other players feel slighted and the game is ruined.
Reconstructed: Seamus's girlfriend is new to gaming, and his preferential treatment encourages her to keep playing and improve her skills. Eventually, she doesn't need any extra help and he stops favoring her. Gaming together improves their relationship.
Played For Laughs: Seamus's girlfriend is really, really bad at the game, and has dismal luck with the dice, but Seamus keeps going easy on her. "All right, roll to see if the arrow hits... Roll to see where it hits...Roll to see if you blinked... The arrow bounces off of your eyelid! No damage!"